Barbara N Morrison, Peter M Mittermaier, Garth R Lester, Michael E Bodner, Anita T Cote
{"title":"与有氧能力相关的心室-血管相互作用的性别差异。","authors":"Barbara N Morrison, Peter M Mittermaier, Garth R Lester, Michael E Bodner, Anita T Cote","doi":"10.1186/s44156-024-00066-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Aerobic capacity measured by maximal oxygen uptake (VO<sub>2</sub>max) is related to functional capacity and is a strong independent predictor of all-cause and disease-specific mortality. Sex-specific cardiac and vascular responses to endurance training have been observed, however, their relative contributions to VO<sub>2</sub>max are less understood. The purpose of this study was to evaluate sex-specific ventricular-vascular interactions associated with VO<sub>2</sub>max in healthy males and females.</p><p><strong>Methods: </strong>Sixty-eight males and females (38% females, 35 ± 10y) characterised as recreational exercisers to highly trained endurance athletes, and free of chronic disease underwent a cycle ergometer to assess VO<sub>2</sub>max. Resting arterial compliance and echocardiographic evaluation of left ventricular (LV) structure and function were measured and indexed to body surface area.</p><p><strong>Results: </strong>VO<sub>2</sub>max was similar between groups (54 ± 6 vs. 50 ± 7 ml/kg/min, p = 0.049). Indexed LV mass (LVMi) was higher (96 ± 15 vs. 81 ± 11, p = 0.001) in males versus females, respectively. Linear regression analysis revealed two models that were significantly associated with VO<sub>2</sub>max in males and females. In males, the two models included (1) longitudinal diastolic strain rate and LVMi (r<sup>2</sup> = 0.31, p = 0.003) and (2) indexed end-diastolic volume (EDVi) and longitudinal diastolic strain rate (r<sup>2</sup> = 0.34, p < 0.001). In females, the linear regression models included (1) LVMi, large arterial compliance, longitudinal systolic strain rate, and age (r<sup>2</sup> = 0.69, p < 0.001) and (2) EDVi, large arterial compliance, longitudinal systolic strain rate, and age (r<sup>2</sup> = 0.52, p = 0.003).</p><p><strong>Conclusion: </strong>These findings reveal that while in both sexes, LVMi and LVEDVi are associated with VO<sub>2</sub>max, arterial compliance was also found to contribute to the variance in VO<sub>2</sub> max in females, but not in males. Further, ventricular relaxation was a significant factor in aerobic capacity in males, while in females ventricular contraction was a significant factor.</p>","PeriodicalId":45749,"journal":{"name":"Echo Research and Practice","volume":"12 1","pages":"2"},"PeriodicalIF":3.2000,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744966/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sex differences in ventricular-vascular interactions associated with aerobic capacity.\",\"authors\":\"Barbara N Morrison, Peter M Mittermaier, Garth R Lester, Michael E Bodner, Anita T Cote\",\"doi\":\"10.1186/s44156-024-00066-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Aerobic capacity measured by maximal oxygen uptake (VO<sub>2</sub>max) is related to functional capacity and is a strong independent predictor of all-cause and disease-specific mortality. Sex-specific cardiac and vascular responses to endurance training have been observed, however, their relative contributions to VO<sub>2</sub>max are less understood. The purpose of this study was to evaluate sex-specific ventricular-vascular interactions associated with VO<sub>2</sub>max in healthy males and females.</p><p><strong>Methods: </strong>Sixty-eight males and females (38% females, 35 ± 10y) characterised as recreational exercisers to highly trained endurance athletes, and free of chronic disease underwent a cycle ergometer to assess VO<sub>2</sub>max. Resting arterial compliance and echocardiographic evaluation of left ventricular (LV) structure and function were measured and indexed to body surface area.</p><p><strong>Results: </strong>VO<sub>2</sub>max was similar between groups (54 ± 6 vs. 50 ± 7 ml/kg/min, p = 0.049). Indexed LV mass (LVMi) was higher (96 ± 15 vs. 81 ± 11, p = 0.001) in males versus females, respectively. Linear regression analysis revealed two models that were significantly associated with VO<sub>2</sub>max in males and females. In males, the two models included (1) longitudinal diastolic strain rate and LVMi (r<sup>2</sup> = 0.31, p = 0.003) and (2) indexed end-diastolic volume (EDVi) and longitudinal diastolic strain rate (r<sup>2</sup> = 0.34, p < 0.001). In females, the linear regression models included (1) LVMi, large arterial compliance, longitudinal systolic strain rate, and age (r<sup>2</sup> = 0.69, p < 0.001) and (2) EDVi, large arterial compliance, longitudinal systolic strain rate, and age (r<sup>2</sup> = 0.52, p = 0.003).</p><p><strong>Conclusion: </strong>These findings reveal that while in both sexes, LVMi and LVEDVi are associated with VO<sub>2</sub>max, arterial compliance was also found to contribute to the variance in VO<sub>2</sub> max in females, but not in males. 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引用次数: 0
摘要
背景：由最大摄氧量（VO2max）测量的有氧能力与功能能力相关，是全因死亡率和疾病特异性死亡率的一个强有力的独立预测指标。性别特异性的心脏和血管对耐力训练的反应已经被观察到，然而，它们对最大摄氧量的相对贡献还不太清楚。本研究的目的是评估健康男性和女性中与VO2max相关的性别特异性脑室-血管相互作用。方法：68名男性和女性（38%女性，35±10岁），从休闲锻炼者到训练有素的耐力运动员，无慢性疾病，采用循环测力仪评估VO2max。静息动脉顺应性和超声心动图评价左心室（LV）的结构和功能，并与体表面积指数。结果：两组VO2max差异无统计学意义（54±6 vs 50±7 ml/kg/min, p = 0.049）。索引左室质量（LVMi）男性高于女性（96±15比81±11，p = 0.001）。线性回归分析显示两个模型与男性和女性的最大摄氧量显著相关。在男性中，两种模型包括(1)纵向舒张应变率和LVMi （r2 = 0.31, p = 0.003）和(2)指数舒张末期容积（EDVi）和纵向舒张应变率（r2 = 0.34, p 2 = 0.69, p 2 = 0.52, p = 0.003）。结论：这些研究结果表明，尽管在两性中，LVMi和LVEDVi与VO2max有关，但动脉顺应性也被发现有助于女性VO2max的变化，但在男性中没有。此外，男性心室舒张是有氧能力的重要因素，而女性心室收缩是有氧能力的重要因素。
Sex differences in ventricular-vascular interactions associated with aerobic capacity.
Background: Aerobic capacity measured by maximal oxygen uptake (VO2max) is related to functional capacity and is a strong independent predictor of all-cause and disease-specific mortality. Sex-specific cardiac and vascular responses to endurance training have been observed, however, their relative contributions to VO2max are less understood. The purpose of this study was to evaluate sex-specific ventricular-vascular interactions associated with VO2max in healthy males and females.
Methods: Sixty-eight males and females (38% females, 35 ± 10y) characterised as recreational exercisers to highly trained endurance athletes, and free of chronic disease underwent a cycle ergometer to assess VO2max. Resting arterial compliance and echocardiographic evaluation of left ventricular (LV) structure and function were measured and indexed to body surface area.
Results: VO2max was similar between groups (54 ± 6 vs. 50 ± 7 ml/kg/min, p = 0.049). Indexed LV mass (LVMi) was higher (96 ± 15 vs. 81 ± 11, p = 0.001) in males versus females, respectively. Linear regression analysis revealed two models that were significantly associated with VO2max in males and females. In males, the two models included (1) longitudinal diastolic strain rate and LVMi (r2 = 0.31, p = 0.003) and (2) indexed end-diastolic volume (EDVi) and longitudinal diastolic strain rate (r2 = 0.34, p < 0.001). In females, the linear regression models included (1) LVMi, large arterial compliance, longitudinal systolic strain rate, and age (r2 = 0.69, p < 0.001) and (2) EDVi, large arterial compliance, longitudinal systolic strain rate, and age (r2 = 0.52, p = 0.003).
Conclusion: These findings reveal that while in both sexes, LVMi and LVEDVi are associated with VO2max, arterial compliance was also found to contribute to the variance in VO2 max in females, but not in males. Further, ventricular relaxation was a significant factor in aerobic capacity in males, while in females ventricular contraction was a significant factor.
期刊介绍：
Echo Research and Practice aims to be the premier international journal for physicians, sonographers, nurses and other allied health professionals practising echocardiography and other cardiac imaging modalities. This open-access journal publishes quality clinical and basic research, reviews, videos, education materials and selected high-interest case reports and videos across all echocardiography modalities and disciplines, including paediatrics, anaesthetics, general practice, acute medicine and intensive care. Multi-modality studies primarily featuring the use of cardiac ultrasound in clinical practice, in association with Cardiac Computed Tomography, Cardiovascular Magnetic Resonance or Nuclear Cardiology are of interest. Topics include, but are not limited to: 2D echocardiography 3D echocardiography Comparative imaging techniques – CCT, CMR and Nuclear Cardiology Congenital heart disease, including foetal echocardiography Contrast echocardiography Critical care echocardiography Deformation imaging Doppler echocardiography Interventional echocardiography Intracardiac echocardiography Intraoperative echocardiography Prosthetic valves Stress echocardiography Technical innovations Transoesophageal echocardiography Valve disease.
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