多菌株年龄结构流行病模型的数值动力学与最优控制。

IF 2.2 4区 数学 Q2 BIOLOGY Journal of Mathematical Biology Pub Date : 2025-01-16 DOI:10.1007/s00285-024-02180-y
Zhijie Chen, Hanmeng Feng
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引用次数: 0

摘要

本文提出了一种同时考虑多种病毒株的年龄结构流行病学模型。我们建立了一个线性隐式欧拉方法研究动力学和最优控制的数值框架,其中生物学意义是无条件保留的。从一致数值有界性出发,导出了有限时间内数值解的一阶收敛性。数值动力学由数值基本再现数rh决定,rh反映了平衡点的渐近稳定性。该抽象框架为研究多菌株流行病模型的长期行为提供了一种有效和统一的方法,涵盖了各种已知模型,并为多菌株年龄结构SIR模型提供了数值最优控制策略。最后,通过数值仿真验证了本文研究结果的正确性和有效性。
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Numerical dynamics and optimal control for multi-strain age-structured epidemic model.

In this paper, a novel age-structured epidemiological model that simultaneously considers multiple viral strains is proposed. We develop a numerical framework for the study of the dynamics and optimal control by a linearly implicit Euler method, in which the biological meaning is unconditionally preserved. The first order convergence of numerical solutions in a finite time is derived from a uniform numerical boundedness. Moreover, the numerical dynamics are determined by a numerical basic reproduction number R h , which reflects the asymptotic stability of the equilibrium points. The abstract framework offers an effective and unified approach to study the long-time behaviour of multi-strain epidemic models that cover a wide variety of well-known models, which also provides a numerical optimal control strategy of the multi-strain age-structured SIR model. Finally, some numerical simulations illustrate the verification and the efficiency of our results.

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来源期刊
CiteScore
3.30
自引率
5.30%
发文量
120
审稿时长
6 months
期刊介绍: The Journal of Mathematical Biology focuses on mathematical biology - work that uses mathematical approaches to gain biological understanding or explain biological phenomena. Areas of biology covered include, but are not restricted to, cell biology, physiology, development, neurobiology, genetics and population genetics, population biology, ecology, behavioural biology, evolution, epidemiology, immunology, molecular biology, biofluids, DNA and protein structure and function. All mathematical approaches including computational and visualization approaches are appropriate.
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