Resensitization—Should Repeat Testing Be Performed in Patients Undergoing Penicillin Allergy Evaluations? A Pro–Con Debate

Evaluating penicillin allergy labels and expanding access to preferred treatment options safely is of critical public health importance. Most patients with penicillin allergy labels are not allergic, and even in those with verified allergy, sensitization wanes over time. However, sensitization is complex, and whereas a patient may have a negative penicillin allergy evaluation (including a drug challenge), resensitization can occur, raising a risk of a subsequent reaction on exposure. In this pro–con debate we deliberate on whether patients who have had negative penicillin allergy evaluations should undergo retesting for sensitization before subsequent administrations. The pro position is presented by Drs Inmaculada Doña, María Salas, and María Torres, whereas the con position is described by Drs Ami Belmont and Roland Solensky.