Filippo Cieri, Giulia Di Francesco, Chad Lee Cross, Andrew Bender, Jessica Zoe Kirkland Caldwell
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Kaiser–Meyer–Olkin (KMO) = 0.80 and Bartlett's test of sphericity indicated all values ≤0.01; Cronbach's alpha = 0.83.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>We have validated a reliable, novel, easy to complete, and comprehensive scale to assess lifetime behaviors, which can be applied in research on AD risk reduction, mild cognitive impairment, and in clinical practice.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Reserve, resistance, and resilience share similar adaptive mechanisms.</li>\n \n <li>Dynamic Neurocognitive Adaptation is a new scale to assess lifetime protective factors.</li>\n \n <li>Dynamic Neurocognitive Adaptation is a reliable, novel, and easy to complete scale.</li>\n \n <li>This approach can characterize specific life stages that are ripe for risk-reduction interventions.</li>\n \n <li>Our scale can be used to personalize health recommendations in aging.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":53225,"journal":{"name":"Alzheimer''s and Dementia: Translational Research and Clinical Interventions","volume":"11 1","pages":""},"PeriodicalIF":4.9000,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11746070/pdf/","citationCount":"0","resultStr":"{\"title\":\"Dynamic neurocognitive adaptation in aging: Development and validation of a new scale\",\"authors\":\"Filippo Cieri, Giulia Di Francesco, Chad Lee Cross, Andrew Bender, Jessica Zoe Kirkland Caldwell\",\"doi\":\"10.1002/trc2.70049\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> INTRODUCTION</h3>\\n \\n <p>Forty-five percent of Alzheimer's disease (AD) cases may have been preventable through protective factors. 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Dynamic neurocognitive adaptation in aging: Development and validation of a new scale
INTRODUCTION
Forty-five percent of Alzheimer's disease (AD) cases may have been preventable through protective factors. Reserve, resilience, and resistance share common neurocognitive adaptive processes, acting through protective mechanisms. In this article we propose the development and validation of a new scale, called dynamic Neurocognitive Adaptation, developed in this direction.
METHODS
We included 815 participants (50% women; 65+ years inclusive of age), divided into two subsamples for exploratory and confirmatory factor analysis. Our initial scale was composed of 30 items, investigating seven dimensions, explored by a 5-point Likert scale reflecting the frequency of activities, for seven time windows.
RESULTS
Our final scale had 20 items divided among four dimensions: physical, cognitive, creative, and social. There were no issues related to multi-collinearity or non-collinearity. Kaiser–Meyer–Olkin (KMO) = 0.80 and Bartlett's test of sphericity indicated all values ≤0.01; Cronbach's alpha = 0.83.
DISCUSSION
We have validated a reliable, novel, easy to complete, and comprehensive scale to assess lifetime behaviors, which can be applied in research on AD risk reduction, mild cognitive impairment, and in clinical practice.
Highlights
Reserve, resistance, and resilience share similar adaptive mechanisms.
Dynamic Neurocognitive Adaptation is a new scale to assess lifetime protective factors.
Dynamic Neurocognitive Adaptation is a reliable, novel, and easy to complete scale.
This approach can characterize specific life stages that are ripe for risk-reduction interventions.
Our scale can be used to personalize health recommendations in aging.
期刊介绍：
Alzheimer''s & Dementia: Translational Research & Clinical Interventions (TRCI) is a peer-reviewed, open access,journal from the Alzheimer''s Association®. The journal seeks to bridge the full scope of explorations between basic research on drug discovery and clinical studies, validating putative therapies for aging-related chronic brain conditions that affect cognition, motor functions, and other behavioral or clinical symptoms associated with all forms dementia and Alzheimer''s disease. The journal will publish findings from diverse domains of research and disciplines to accelerate the conversion of abstract facts into practical knowledge: specifically, to translate what is learned at the bench into bedside applications. The journal seeks to publish articles that go beyond a singular emphasis on either basic drug discovery research or clinical research. Rather, an important theme of articles will be the linkages between and among the various discrete steps in the complex continuum of therapy development. For rapid communication among a multidisciplinary research audience involving the range of therapeutic interventions, TRCI will consider only original contributions that include feature length research articles, systematic reviews, meta-analyses, brief reports, narrative reviews, commentaries, letters, perspectives, and research news that would advance wide range of interventions to ameliorate symptoms or alter the progression of chronic neurocognitive disorders such as dementia and Alzheimer''s disease. The journal will publish on topics related to medicine, geriatrics, neuroscience, neurophysiology, neurology, psychiatry, clinical psychology, bioinformatics, pharmaco-genetics, regulatory issues, health economics, pharmacoeconomics, and public health policy as these apply to preclinical and clinical research on therapeutics.
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