同行评议盲法分析测试(P-BAT):国家管制的大麻市场的无信任实验室质量保证框架。

IF 4.1 Q1 PHARMACOLOGY & PHARMACY Journal of cannabis research Pub Date : 2025-01-21 DOI:10.1186/s42238-025-00261-3
Stuart Procter, Grayson L Baird, Jason Iannuccilli
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引用次数: 0

摘要

在大麻工业中进行实验室检测的目的是通过防止超过污染物危险限度的产品接触到消费者,确保公共安全,并向消费者提供透明和准确的标签信息,以便他们在购买和使用产品时作出知情决定。然而,大麻测试并非存在于激励机制的真空中——某些激励机制的存在与消费者的最佳利益直接冲突。例如,种植者和经销商将更愿意使用发现最高四氢大麻酚浓度或最低污染物浓度的实验室的服务,而不管其测试结果的准确性。因此,实验室将被激励为种植者和分销商服务,而不是最终消费者。本文提出了一个质量保证框架,以对抗这些不正当的激励。以下提议的框架称为同行评审盲法分析测试(P-BAT),是一个验证过程,其中每个实验室测试来自竞争实验室和自己实验室的产品,但以盲法的方式确保所述产品和生产所述标签的实验室的标签值是未知的。这种盲目的自我审查和同行审查的系统被设计成具有成本效益,透明,几乎是自费的,可以在任何有两个或更多实验室的州实施,最重要的是,它是不可信的——没有必要相信任何一个参与者或实验室的行为作为“黄金标准”。虽然该流程的主要目标是关注实验室性能,但它也将突出行业中的其他常见问题,如分销商的产品掺假和不良的存储操作。P-BAT的数据应该是公开的,这样消费者就可以根据P-BAT得出的质量数据做出明智的购买决定。这样做将进一步激励实验室服务并对最终消费者负责,而不是对种植者和分销商负责。
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Peer-review Blinded Assay Test (P-BAT): a framework for trustless laboratory quality assurance for state-regulated cannabis markets.

The purpose of laboratory testing in the cannabis industry is to ensure public safety by preventing products that exceed hazardous limits of contaminants from reaching consumers, and to provide consumers with transparent and accurate label information so that they can make informed decisions when purchasing and using products. However, cannabis testing does not exist in a vacuum of incentives-some incentives exist that are in direct conflict with what is best for consumers. For example, cultivators and distributors will prefer to use the services of laboratories that find the highest THC concentrations or lowest contaminant concentrations, regardless of the accuracy of their testing results. Laboratories will, therefore, be incentivized to serve the cultivators and distributors over the end consumer. The present essay proposes a framework for quality assurance that combats these perverse incentives. The following proposed framework called the Peer-review Blinded Assay Test (P-BAT), is a validation process where each laboratory tests products from competing labs and their own lab, but in a blinded fashion to ensure that the label values of said products and the labs that produced said labels, are unknown. This system of blinded self-review and peer-review is designed to be cost-efficient, transparent, nearly self-funded, can be implemented in any state with two or more laboratories, and most importantly, it is trustless-there is no need to trust the behavior of any one actor or laboratory to serve as a "gold standard". While the primary objective of this process is to focus on laboratory performance, it will also highlight other common problems in the industry such as product adulteration by distributors and poor storge practices. Data from P-BAT should be publicly available so consumers can make informed decisions about their purchases based on the quality data derived from P-BAT. Doing so would further incentivize laboratories to serve and be accountable to the end consumer instead of cultivators and distributors.

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Bridging past and present: exploring Cannabis traditions in Armenia through ethnobotanical interviews and bibliographic prospecting. Feasibility pilot of a novel coaching intervention to optimize cannabis use for chronic pain management among Veterans. Oral cannabidiol did not impair learning and memory in healthy adults. CBD for pets: navigating quality assurance, safety standards, and marketing strategies. Peer-review Blinded Assay Test (P-BAT): a framework for trustless laboratory quality assurance for state-regulated cannabis markets.
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