妊娠期糖尿病：母体和胎儿并发症的机制。

IF 4.2 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2025-01-23 DOI:10.3803/EnM.2024.2264

Jooyeop Lee, Na Keum Lee, Joon Ho Moon

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摘要

妊娠期糖尿病（GDM）影响超过10%的怀孕，无论是在韩国和世界各地。GDM不仅增加了先兆子痫、早产、巨大儿、新生儿低血糖、肩难产等不良妊娠结局的风险，而且显著增加了母亲发生产后2型糖尿病和心血管疾病的风险。此外，GDM与后代患儿童肥胖和糖尿病的风险较高，以及包括自闭症谱系障碍在内的神经发育障碍有关。本文综述了有关母胎并发症的临床流行病学研究的综合总结，并探讨了揭示潜在病理生理学的机制调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gestational Diabetes Mellitus: Mechanisms Underlying Maternal and Fetal Complications.

Gestational diabetes mellitus (GDM) affects over 10% of all pregnancies, both in Korea and worldwide. GDM not only increases the risk of adverse pregnancy outcomes such as preeclampsia, preterm birth, macrosomia, neonatal hypoglycemia, and shoulder dystocia, but it also significantly increases the risk of developing postpartum type 2 diabetes mellitus and cardiovascular disease in the mother. Additionally, GDM is linked to a higher risk of childhood obesity and diabetes in offspring, as well as neurodevelopmental disorders, including autistic spectrum disorder. This review offers a comprehensive summary of clinical epidemiological studies concerning maternal and fetal complications and explores mechanistic investigations that reveal the underlying pathophysiology.

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来源期刊

Endocrinology and Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.60

自引率

5.90%

发文量

145

审稿时长

24 weeks

期刊介绍： The aim of this journal is to set high standards of medical care by providing a forum for discussion for basic, clinical, and translational researchers and clinicians on new findings in the fields of endocrinology and metabolism. Endocrinology and Metabolism reports new findings and developments in all aspects of endocrinology and metabolism. The topics covered by this journal include bone and mineral metabolism, cytokines, developmental endocrinology, diagnostic endocrinology, endocrine research, dyslipidemia, endocrine regulation, genetic endocrinology, growth factors, hormone receptors, hormone action and regulation, management of endocrine diseases, clinical trials, epidemiology, molecular endocrinology, neuroendocrinology, neuropeptides, neurotransmitters, obesity, pediatric endocrinology, reproductive endocrinology, signal transduction, the anatomy and physiology of endocrine organs (i.e., the pituitary, thyroid, parathyroid, and adrenal glands, and the gonads), and endocrine diseases (diabetes, nutrition, osteoporosis, etc.).