{"title":"印尼药用植物抗肥胖药物对胰脂肪酶的强抑制作用。","authors":"Min Rahminiwati, Dyah Iswantini, Trivadila, Rut Novalia Rahmawati Sianipar, Rani Melati Sukma, Susi Indariani, Anggia Murni","doi":"10.3390/cimb47010039","DOIUrl":null,"url":null,"abstract":"<p><p>Obesity is characterized by the accumulation of excessive fat, potentially leading to degenerative diseases. Pancreatic lipase, an enzyme responsible for converting 50-70% of dietary fat into monoglycerides, free fatty acids, and various other smaller molecules, plays a crucial role in fat metabolism. Therefore, this study aimed to review selected Indonesian medicinal plants with the potential to inhibit the activity of the pancreatic lipase enzyme. The results showed that kunci pepet (<i>Kaempferiae angustifolia</i> Rosc.), asam gelugur (<i>Garcinia atroviridis</i>), temulawak (<i>Curcuma xanthorrhiza</i>), jombang (<i>Taraxacum officinale</i> F. H. Wigg), pegagan (<i>Centella asiatica</i>), and pala (<i>Myristica fragrans</i>) had strong inhibitory effects, exceeding 50% for both in vitro and in vivo studies. Therefore, further studies are needed to explore the potential of these medicinal plants as anti-obesity treatments.</p>","PeriodicalId":10839,"journal":{"name":"Current Issues in Molecular Biology","volume":"47 1","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764437/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Strong Inhibition of Pancreatic Lipase by Selected Indonesian Medicinal Plants as Anti-Obesity Agents.\",\"authors\":\"Min Rahminiwati, Dyah Iswantini, Trivadila, Rut Novalia Rahmawati Sianipar, Rani Melati Sukma, Susi Indariani, Anggia Murni\",\"doi\":\"10.3390/cimb47010039\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Obesity is characterized by the accumulation of excessive fat, potentially leading to degenerative diseases. Pancreatic lipase, an enzyme responsible for converting 50-70% of dietary fat into monoglycerides, free fatty acids, and various other smaller molecules, plays a crucial role in fat metabolism. Therefore, this study aimed to review selected Indonesian medicinal plants with the potential to inhibit the activity of the pancreatic lipase enzyme. The results showed that kunci pepet (<i>Kaempferiae angustifolia</i> Rosc.), asam gelugur (<i>Garcinia atroviridis</i>), temulawak (<i>Curcuma xanthorrhiza</i>), jombang (<i>Taraxacum officinale</i> F. H. Wigg), pegagan (<i>Centella asiatica</i>), and pala (<i>Myristica fragrans</i>) had strong inhibitory effects, exceeding 50% for both in vitro and in vivo studies. Therefore, further studies are needed to explore the potential of these medicinal plants as anti-obesity treatments.</p>\",\"PeriodicalId\":10839,\"journal\":{\"name\":\"Current Issues in Molecular Biology\",\"volume\":\"47 1\",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-01-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764437/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Issues in Molecular Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.3390/cimb47010039\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Issues in Molecular Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3390/cimb47010039","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
肥胖的特点是积累过多的脂肪，可能导致退行性疾病。胰脂肪酶是一种将50-70%的膳食脂肪转化为单甘油酯、游离脂肪酸和其他各种小分子的酶，在脂肪代谢中起着至关重要的作用。因此，本研究旨在综述精选的具有抑制胰脂肪酶活性潜力的印度尼西亚药用植物。结果表明，孔慈桃（Kaempferiae angustifolia Rosc.）、黄姜（Garcinia atroviridis）、黄姜（Curcuma xanthorrhiza）、仲bang （Taraxacum officinale F. H. Wigg）、pegagan （Centella asiatica）和pala （Myristica fragrans）具有较强的体外和体内抑制作用，均超过50%。因此，需要进一步研究这些药用植物作为抗肥胖治疗的潜力。
The Strong Inhibition of Pancreatic Lipase by Selected Indonesian Medicinal Plants as Anti-Obesity Agents.
Obesity is characterized by the accumulation of excessive fat, potentially leading to degenerative diseases. Pancreatic lipase, an enzyme responsible for converting 50-70% of dietary fat into monoglycerides, free fatty acids, and various other smaller molecules, plays a crucial role in fat metabolism. Therefore, this study aimed to review selected Indonesian medicinal plants with the potential to inhibit the activity of the pancreatic lipase enzyme. The results showed that kunci pepet (Kaempferiae angustifolia Rosc.), asam gelugur (Garcinia atroviridis), temulawak (Curcuma xanthorrhiza), jombang (Taraxacum officinale F. H. Wigg), pegagan (Centella asiatica), and pala (Myristica fragrans) had strong inhibitory effects, exceeding 50% for both in vitro and in vivo studies. Therefore, further studies are needed to explore the potential of these medicinal plants as anti-obesity treatments.
期刊介绍：
Current Issues in Molecular Biology (CIMB) is a peer-reviewed journal publishing review articles and minireviews in all areas of molecular biology and microbiology. Submitted articles are subject to an Article Processing Charge (APC) and are open access immediately upon publication. All manuscripts undergo a peer-review process.
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