Mingyi Yang, Yani Su, Pengfei Wen, Jiale Xie, Xianjie Wan, Ke Xu, Wensen Jing, Zhi Yang, Lin Liu, Peng Xu
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引用次数: 0
摘要
目的：深静脉血栓形成（DVT）是一种已知的骨折并发症。本研究旨在探讨深静脉血栓形成与骨折部位的遗传因果关系。研究设计与方法：本研究分析的暴露点包括股骨骨折（FFE）、小腿包括踝关节骨折（FLLA）、肩及上臂骨折（FSUA）、前臂骨折（FFO）、肋骨、胸骨和胸椎骨折（FRSTS）和腰椎和骨盆骨折（FLSP）。结果是深静脉血栓。采用双样本孟德尔随机化（MR）方法研究遗传因果关系，并进行一系列敏感性分析。结果:研究结果显示没有遗传之间的因果关系企业(p = 0.569, 95% CI = 1.001 [0.998 - -1.003]), FLLA (p = 0.371, 95% CI = 0.999 [0.995 - -1.002]), FSUA (p = 0.871, 95% CI = 1.000 [0.998 - -1.002]), FFO (p = 0.281, 95% CI = 1.001[0.999 - -1.002]),第一(p = 0.346, 95% CI = 0.999[0.996 - -1.001])或FLSP (p = 0.759, 95% CI = 1.000[0.999 - -1.002])和深静脉血栓形成。敏感性分析增强了稳健性。结论：本研究提示DVT与骨折部位之间不存在遗传因果关系，观察到的关联可能归因于非遗传因素。
Is the occurrence of deep vein thrombosis related to the fracture site? A two-sample Mendelian randomization study.
Objective: Deep vein thrombosis (DVT) is a known complication of fractures. This study aimed to explore the genetic causal relationship between DVT and fracture sites.
Research design and methods: The exposures analyzed in this study included fracture of femur (FFE), fracture of lower leg, including ankle (FLLA), fracture of shoulder and upper arm (FSUA), fracture of forearm (FFO), fracture of rib, sternum and thoracic spine (FRSTS) and fracture of lumbar spine and pelvis (FLSP). DVT as the outcome. A two-sample Mendelian randomization (MR) approach was employed to investigate the genetic causal relationship, and a series of sensitivity analyses were conducted.
Results: The findings indicated no genetic causal relationship between FFE (p = 0.569, OR 95% CI = 1.001 [0.998-1.003]), FLLA (p = 0.371, OR 95% CI = 0.999 [0.995-1.002]), FSUA (p = 0.871, OR 95% CI = 1.000 [0.998-1.002]), FFO (p = 0.281, OR 95% CI = 1.001 [0.999-1.002]), FRSTS (p = 0.346, OR 95% CI = 0.999 [0.996-1.001]) or FLSP (p = 0.759, OR 95% CI = 1.000 [0.999-1.002]) and DVT. Sensitivity analyses reinforced the robustness.
Conclusions: This study indicate that no genetic causal relationship exists between DVT and fracture site, the observed association may be attributable to non-genetic factors.
期刊介绍：
Advanced molecular research techniques have transformed hematology in recent years. With improved understanding of hematologic diseases, we now have the opportunity to research and evaluate new biological therapies, new drugs and drug combinations, new treatment schedules and novel approaches including stem cell transplantation. We can also expect proteomics, molecular genetics and biomarker research to facilitate new diagnostic approaches and the identification of appropriate therapies. Further advances in our knowledge regarding the formation and function of blood cells and blood-forming tissues should ensue, and it will be a major challenge for hematologists to adopt these new paradigms and develop integrated strategies to define the best possible patient care. Expert Review of Hematology (1747-4086) puts these advances in context and explores how they will translate directly into clinical practice.
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