从1965年到2023年发现的生物活性安古昔环类药物。

IF 5.7 2区医学 Q1 CHEMISTRY, MEDICINAL Marine Drugs Pub Date : 2025-01-05 DOI:10.3390/md23010025

Hai-Shan Liu, Hui-Ru Chen, Shan-Shan Huang, Zi-Hao Li, Chun-Ying Wang, Hua Zhang

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摘要

Angucyclines/angucyclinones是一类具有多种化学结构的聚酮类化合物，具有抗菌或抗真菌、抗癌、抗神经炎和抗-α-葡萄糖苷酶等多种生物活性。海洋和陆地微生物对生物活性氨环素/氨环素类的发现作出了重大贡献。本文综述了从1965年到2023年发现的283种生物活性氨环素/氨环素类药物，重点介绍了这些有趣的天然产物的生物学起源、化学结构和生物活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bioactive Angucyclines/Angucyclinones Discovered from 1965 to 2023.

Angucyclines/angucyclinones, a class of polyketides with diverse chemical structures, display various bioactivities including antibacterial or antifungal, anticancer, anti-neuroinflammatory, and anti-α-glucosidase activities. Marine and terrestrial microorganisms have made significant contributions to the discovery of bioactive angucyclines/angucyclinones. This review covers 283 bioactive angucyclines/angucyclinones discovered from 1965 to 2023, and the emphasis is on the biological origins, chemical structures, and biological activities of these interesting natural products.

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.