Classification and treatment approach of chemical burn associated Limbal stem cell deficiency: based on novel global consensus.

Purpose: To evaluate the severity distribution of chemical burn-induced Limbal stem cell deficiency (LSCD) according to the novel global consensus classification and to compare the treatment approach, before and after the global consensus.

Methods: Medical records of 127 eyes of 109 patients with LSCD were included. LSCD stages were categorized according to the global consensus classification published by "International LSCD Working Group".

Results: The mean age was 37.5 ± 16.5(6-75). The distribution of LSCD stage according to the global consensus scale was as follows: Stage 1A in 5 eyes(3.9%);Stage 1B in 16 eyes(12.6%);Stage 1C in 4 eyes(3.2%);Stage 2A in 15 eyes(11.8%);Stage 2B in 36 eyes(28.3%);Stage 3 in 51 eyes(40.2%). A total of 88(69.3%) eyes underwent surgery for LSCD. Of these, 80 had surgery prior to the publication of the global consensus (before October 2020), 58(72.5%) had preoperative severe (≥ Stage 2B) LSCD and 22(27.5%) had preoperative early stage (≤ Stage 2A) LSCD. As of October 2020, all 8 eyes that underwent surgery had preoperative severe (≥ Stage 2B) LSCD, as recommended by global consensus.

Conclusion: Recently, a global consensus has been established on both the classification and the management of LSCD. This study is one of the first to present small-scale epidemiological data on the severity distribution of LSCD in the light of the global consensus. It was observed that surgery was performed on 27.5% of the eyes that were not recommended for surgery according to this new consensus. With the increasing awareness of this consensus, it might be possible to avoid unnecessary surgical intervention.