从细胞质进入细胞核——乙型肝炎病毒的传播与基因组修复。

IF 4.7 2区生物学 Q2 MICROBIOLOGY Microorganisms Pub Date : 2025-01-14 DOI:10.3390/microorganisms13010157

Johan Ringlander, Gustaf E Rydell, Michael Kann

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引用次数: 0

摘要

乙型肝炎病毒（HBV）是一个主要的全球卫生问题，影响着全世界数百万人。HBV是肝病毒科的一员，是急性和慢性肝脏感染的主要原因之一，可导致肝硬化和肝细胞癌（HCC）等疾病。了解HBV的细胞内转运和基因组修复机制对于开发新药至关重要，这些药物与免疫调节剂联合使用可能有助于潜在的治疗。这篇综述将探讨目前对HBV胞浆内和核内转运以及基因组修复过程的了解，同时与其他具有核复制的病毒进行比较。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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From the Cytoplasm into the Nucleus-Hepatitis B Virus Travel and Genome Repair.

Hepatitis B virus (HBV) is a major global health concern, affecting millions of people worldwide. HBV is part of the hepadnaviridae family and one of the primary causes of acute and chronic liver infections, leading to conditions such as cirrhosis and hepatocellular carcinoma (HCC). Understanding the intracellular transport and genome repair mechanisms of HBV is crucial for developing new drugs, which-in combination with immune modulators-may contribute to potential cures. This review will explore the current knowledge of HBV intracytoplasmic and nuclear transport, as well as genome repair processes, while drawing comparisons to other viruses with nuclear replication.

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来源期刊

Microorganisms Medicine-Microbiology (medical)

CiteScore

7.40

自引率

6.70%

发文量

2168

审稿时长

20.03 days

期刊介绍： Microorganisms (ISSN 2076-2607) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to prokaryotic and eukaryotic microorganisms, viruses and prions. It publishes reviews, research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.