67岁汉族前列腺癌患者诱导多能干细胞FDZSi002-A的衍生

IF 0.7 4区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Stem cell research Pub Date : 2025-03-01 Epub Date: 2025-01-07 DOI:10.1016/j.scr.2025.103659
Chuan-Sheng Hou , zhe zhu , Xue-Feng Xie , Xue-Qiang Lu , Zhuo Chen , Hao-Yu Cui , Hao Wu , Bei Zhang , Chuan-Sheng Hou
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引用次数: 0

摘要

前列腺癌(PCa)是男性生殖系统最常见的恶性肿瘤。在这项研究中,我们从一名确诊为PC的67岁男性患者的外周血单个核细胞(PBMCs)中获得了诱导多能干细胞(iPSC)系。用流式细胞术和免疫荧光法对构建的iPSCs进行鉴定。此外,iPSC系具有正常的染色体核型,并具有在体外自发分化为三胚层的潜力。iPSC细胞系将成为研究PCa发病机制的有用工具。
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Derivation of induced pluripotent stem cell FDZSi002-A from a 67-year-old Chinese Han Prostate cancer patient
Prostate cancer (PCa) is the most common malignant tumor of the male reproductive system. In this study, we generated an induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells (PBMCs) of a 67-year-old male patient and diagnosed with PC. The established iPSCs were confirmed by flow cytometry and immunofluorescence. Furthermore, the iPSC line has a normal chromosomal karyotype and has the potential of spontaneous differentiation into three germ layers in vitro. The iPSC line will be a useful tool for investigating the pathogenesis mechanisms of PCa.
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来源期刊
Stem cell research
Stem cell research 生物-生物工程与应用微生物
CiteScore
2.20
自引率
8.30%
发文量
338
审稿时长
55 days
期刊介绍: Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.
期刊最新文献
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