Wassim Elyaman, Lawrence J. Stern, Ning Jiang, Dallin Dressman, Philip Bradley, David Klatzmann, Elizabeth M. Bradshaw, Donna L. Farber, Sally C. Kent, Shahab Chizari, Kristen Funk, Davangere Devanand, Kiran T. Thakur, Towfique Raj, Osama Al Dalahmah, Rani A. Sarkis, Howard L. Weiner, Neil A. Shneider, Serge Przedborski
{"title":"探索T细胞在阿尔茨海默病和其他神经退行性疾病中的作用：来自大脑T细胞研讨会的新治疗见解","authors":"Wassim Elyaman, Lawrence J. Stern, Ning Jiang, Dallin Dressman, Philip Bradley, David Klatzmann, Elizabeth M. Bradshaw, Donna L. Farber, Sally C. Kent, Shahab Chizari, Kristen Funk, Davangere Devanand, Kiran T. Thakur, Towfique Raj, Osama Al Dalahmah, Rani A. Sarkis, Howard L. Weiner, Neil A. Shneider, Serge Przedborski","doi":"10.1002/alz.14548","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <p>This proceedings article summarizes the inaugural “T Cells in the Brain” symposium held at Columbia University. Experts gathered to explore the role of T cells in neurodegenerative diseases. Key topics included characterization of antigen-specific immune responses, T cell receptor (TCR) repertoire, microbial etiology in Alzheimer's disease (AD), and microglia–T cell crosstalk, with a focus on how T cells affect neuroinflammation and AD biomarkers like amyloid beta and tau. The symposium also examined immunotherapies for AD, including the Valacyclovir Treatment of Alzheimer's Disease (VALAD) trial, and two clinical trials leveraging regulatory T cell approaches for multiple sclerosis and amyotrophic lateral sclerosis therapy. Additionally, single-cell RNA/TCR sequencing of T cells and other immune cells provided insights into immune dynamics in neurodegenerative diseases. This article highlights key findings from the symposium and outlines future research directions to further understand the role of T cells in neurodegeneration, offering innovative therapeutic approaches for AD and other neurodegenerative diseases.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Researchers gathered to discuss approaches to study T cells in brain disorders.</li>\n \n <li>New technologies allow high-throughput screening of antigen-specific T cells.</li>\n \n <li>Microbial infections can precede several serious and chronic neurological diseases.</li>\n \n <li>Central and peripheral T cell responses shape neurological disease pathology.</li>\n \n <li>Immunotherapy can induce regulatory T cell responses in neuroinflammatory disorders.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 2","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.14548","citationCount":"0","resultStr":"{\"title\":\"Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium\",\"authors\":\"Wassim Elyaman, Lawrence J. Stern, Ning Jiang, Dallin Dressman, Philip Bradley, David Klatzmann, Elizabeth M. Bradshaw, Donna L. Farber, Sally C. Kent, Shahab Chizari, Kristen Funk, Davangere Devanand, Kiran T. Thakur, Towfique Raj, Osama Al Dalahmah, Rani A. Sarkis, Howard L. Weiner, Neil A. Shneider, Serge Przedborski\",\"doi\":\"10.1002/alz.14548\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <p>This proceedings article summarizes the inaugural “T Cells in the Brain” symposium held at Columbia University. Experts gathered to explore the role of T cells in neurodegenerative diseases. Key topics included characterization of antigen-specific immune responses, T cell receptor (TCR) repertoire, microbial etiology in Alzheimer's disease (AD), and microglia–T cell crosstalk, with a focus on how T cells affect neuroinflammation and AD biomarkers like amyloid beta and tau. The symposium also examined immunotherapies for AD, including the Valacyclovir Treatment of Alzheimer's Disease (VALAD) trial, and two clinical trials leveraging regulatory T cell approaches for multiple sclerosis and amyotrophic lateral sclerosis therapy. Additionally, single-cell RNA/TCR sequencing of T cells and other immune cells provided insights into immune dynamics in neurodegenerative diseases. This article highlights key findings from the symposium and outlines future research directions to further understand the role of T cells in neurodegeneration, offering innovative therapeutic approaches for AD and other neurodegenerative diseases.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>Researchers gathered to discuss approaches to study T cells in brain disorders.</li>\\n \\n <li>New technologies allow high-throughput screening of antigen-specific T cells.</li>\\n \\n <li>Microbial infections can precede several serious and chronic neurological diseases.</li>\\n \\n <li>Central and peripheral T cell responses shape neurological disease pathology.</li>\\n \\n <li>Immunotherapy can induce regulatory T cell responses in neuroinflammatory disorders.</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":7471,\"journal\":{\"name\":\"Alzheimer's & Dementia\",\"volume\":\"21 2\",\"pages\":\"\"},\"PeriodicalIF\":11.1000,\"publicationDate\":\"2025-01-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.14548\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer's & Dementia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14548\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14548","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium
This proceedings article summarizes the inaugural “T Cells in the Brain” symposium held at Columbia University. Experts gathered to explore the role of T cells in neurodegenerative diseases. Key topics included characterization of antigen-specific immune responses, T cell receptor (TCR) repertoire, microbial etiology in Alzheimer's disease (AD), and microglia–T cell crosstalk, with a focus on how T cells affect neuroinflammation and AD biomarkers like amyloid beta and tau. The symposium also examined immunotherapies for AD, including the Valacyclovir Treatment of Alzheimer's Disease (VALAD) trial, and two clinical trials leveraging regulatory T cell approaches for multiple sclerosis and amyotrophic lateral sclerosis therapy. Additionally, single-cell RNA/TCR sequencing of T cells and other immune cells provided insights into immune dynamics in neurodegenerative diseases. This article highlights key findings from the symposium and outlines future research directions to further understand the role of T cells in neurodegeneration, offering innovative therapeutic approaches for AD and other neurodegenerative diseases.
Highlights
Researchers gathered to discuss approaches to study T cells in brain disorders.
New technologies allow high-throughput screening of antigen-specific T cells.
Microbial infections can precede several serious and chronic neurological diseases.
Central and peripheral T cell responses shape neurological disease pathology.
Immunotherapy can induce regulatory T cell responses in neuroinflammatory disorders.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
