Xun He, Chang Zou, Limei Zhang, Peilin Wu, Yongchao Yao, Kai Dong, Yuchun Ren, Wenchuang (Walter) Hu, Yi Li, Han Luo, Binwu Ying, Fengming Luo, Xuping Sun
{"title":"电化学亚硝酸盐还原合成生物医学用途一氧化氮的研究进展。","authors":"Xun He, Chang Zou, Limei Zhang, Peilin Wu, Yongchao Yao, Kai Dong, Yuchun Ren, Wenchuang (Walter) Hu, Yi Li, Han Luo, Binwu Ying, Fengming Luo, Xuping Sun","doi":"10.1002/adhm.202403468","DOIUrl":null,"url":null,"abstract":"<p>Nitric oxide (NO) is an essential molecule in biomedicine, recognized for its antibacterial properties, neuronal modulation, and use in inhalation therapies. The effectiveness of NO-based treatments relies on precise control of NO concentrations tailored to specific therapeutic needs. Electrochemical generation of NO (E-NOgen) via nitrite (NO<sub>2</sub><sup>–</sup>) reduction offers a scalable and efficient route for controlled NO production, while also addressing environmental concerns by reducing NO<sub>2</sub><sup>–</sup> pollution and maintaining nitrogen cycle balance. Recent developments in catalysts and E-NOgen devices have propelled NO<sub>2</sub><sup>–</sup> conversion, enabling on-demand NO production. This review provides an overview of NO<sub>2</sub><sup>−</sup> reduction pathways, with a focus on cutting-edge Fe/Cu-based E-NOgen catalysts, and explores the development of E-NOgen devices for biomedical use. Challenges and future directions for advancing E-NOgen technologies are also discussed.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"14 6","pages":""},"PeriodicalIF":9.6000,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Advances in Electrochemical Nitrite Reduction toward Nitric Oxide Synthesis for Biomedical Applications\",\"authors\":\"Xun He, Chang Zou, Limei Zhang, Peilin Wu, Yongchao Yao, Kai Dong, Yuchun Ren, Wenchuang (Walter) Hu, Yi Li, Han Luo, Binwu Ying, Fengming Luo, Xuping Sun\",\"doi\":\"10.1002/adhm.202403468\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Nitric oxide (NO) is an essential molecule in biomedicine, recognized for its antibacterial properties, neuronal modulation, and use in inhalation therapies. The effectiveness of NO-based treatments relies on precise control of NO concentrations tailored to specific therapeutic needs. Electrochemical generation of NO (E-NOgen) via nitrite (NO<sub>2</sub><sup>–</sup>) reduction offers a scalable and efficient route for controlled NO production, while also addressing environmental concerns by reducing NO<sub>2</sub><sup>–</sup> pollution and maintaining nitrogen cycle balance. Recent developments in catalysts and E-NOgen devices have propelled NO<sub>2</sub><sup>–</sup> conversion, enabling on-demand NO production. This review provides an overview of NO<sub>2</sub><sup>−</sup> reduction pathways, with a focus on cutting-edge Fe/Cu-based E-NOgen catalysts, and explores the development of E-NOgen devices for biomedical use. Challenges and future directions for advancing E-NOgen technologies are also discussed.</p>\",\"PeriodicalId\":113,\"journal\":{\"name\":\"Advanced Healthcare Materials\",\"volume\":\"14 6\",\"pages\":\"\"},\"PeriodicalIF\":9.6000,\"publicationDate\":\"2025-01-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Healthcare Materials\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202403468\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Healthcare Materials","FirstCategoryId":"5","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202403468","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Advances in Electrochemical Nitrite Reduction toward Nitric Oxide Synthesis for Biomedical Applications
Nitric oxide (NO) is an essential molecule in biomedicine, recognized for its antibacterial properties, neuronal modulation, and use in inhalation therapies. The effectiveness of NO-based treatments relies on precise control of NO concentrations tailored to specific therapeutic needs. Electrochemical generation of NO (E-NOgen) via nitrite (NO2–) reduction offers a scalable and efficient route for controlled NO production, while also addressing environmental concerns by reducing NO2– pollution and maintaining nitrogen cycle balance. Recent developments in catalysts and E-NOgen devices have propelled NO2– conversion, enabling on-demand NO production. This review provides an overview of NO2− reduction pathways, with a focus on cutting-edge Fe/Cu-based E-NOgen catalysts, and explores the development of E-NOgen devices for biomedical use. Challenges and future directions for advancing E-NOgen technologies are also discussed.
期刊介绍：
Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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