{"title":"皮质低代谢作为治疗难治性抑郁症患者间歇性θ波爆发刺激反应的预测因子：一项开放标签研究。","authors":"Nidhisha Bajaj, Nand Kumar, Rakesh Kumar, Vaibhav Patil, Anshul Sharma","doi":"10.4103/indianjpsychiatry.indianjpsychiatry_161_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Intermittent theta burst stimulation (iTBS) is an accepted and approved brain stimulation technique to treat patients with treatment-resistant depression.</p><p><strong>Aim: </strong>Using neuroimaging, this open-label study aimed to predict the response by observing glucose metabolism with the help of 18-FDG PET scan.</p><p><strong>Methods: </strong>A total of 25 treatment-resistant depression patients received 15 sessions of iTBS on the left dorsolateral prefrontal cortex. Two FDG-PET scans were done for all the patients. Fifty-six percent of patients responded to treatment with iTBS.</p><p><strong>Results: </strong>We found that there was hypometabolism in left and right prefrontal lateral regions, left and right inferior parietal regions, and left prefrontal medial regions at baseline but no statistically significant difference in the metabolism between responders and nonresponders.</p><p><strong>Conclusion: </strong>We did not find any statistically significant difference in the metabolism between responders and nonresponders in any brain regions at T0 as well as T1. Further large-scale studies are required.</p>","PeriodicalId":13345,"journal":{"name":"Indian Journal of Psychiatry","volume":"66 12","pages":"1154-1158"},"PeriodicalIF":2.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758971/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cortical hypometabolism as a predictor of intermittent theta burst stimulation response in treatment-resistant depression patients: An open-label study.\",\"authors\":\"Nidhisha Bajaj, Nand Kumar, Rakesh Kumar, Vaibhav Patil, Anshul Sharma\",\"doi\":\"10.4103/indianjpsychiatry.indianjpsychiatry_161_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Intermittent theta burst stimulation (iTBS) is an accepted and approved brain stimulation technique to treat patients with treatment-resistant depression.</p><p><strong>Aim: </strong>Using neuroimaging, this open-label study aimed to predict the response by observing glucose metabolism with the help of 18-FDG PET scan.</p><p><strong>Methods: </strong>A total of 25 treatment-resistant depression patients received 15 sessions of iTBS on the left dorsolateral prefrontal cortex. Two FDG-PET scans were done for all the patients. Fifty-six percent of patients responded to treatment with iTBS.</p><p><strong>Results: </strong>We found that there was hypometabolism in left and right prefrontal lateral regions, left and right inferior parietal regions, and left prefrontal medial regions at baseline but no statistically significant difference in the metabolism between responders and nonresponders.</p><p><strong>Conclusion: </strong>We did not find any statistically significant difference in the metabolism between responders and nonresponders in any brain regions at T0 as well as T1. Further large-scale studies are required.</p>\",\"PeriodicalId\":13345,\"journal\":{\"name\":\"Indian Journal of Psychiatry\",\"volume\":\"66 12\",\"pages\":\"1154-1158\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758971/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_161_24\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_161_24","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/12 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Cortical hypometabolism as a predictor of intermittent theta burst stimulation response in treatment-resistant depression patients: An open-label study.
Background: Intermittent theta burst stimulation (iTBS) is an accepted and approved brain stimulation technique to treat patients with treatment-resistant depression.
Aim: Using neuroimaging, this open-label study aimed to predict the response by observing glucose metabolism with the help of 18-FDG PET scan.
Methods: A total of 25 treatment-resistant depression patients received 15 sessions of iTBS on the left dorsolateral prefrontal cortex. Two FDG-PET scans were done for all the patients. Fifty-six percent of patients responded to treatment with iTBS.
Results: We found that there was hypometabolism in left and right prefrontal lateral regions, left and right inferior parietal regions, and left prefrontal medial regions at baseline but no statistically significant difference in the metabolism between responders and nonresponders.
Conclusion: We did not find any statistically significant difference in the metabolism between responders and nonresponders in any brain regions at T0 as well as T1. Further large-scale studies are required.
期刊介绍：
The Indian Journal of Psychiatry (ISSN 0019-5545), is an official publication of the Indian Psychiatric Society. It is published Bimonthly with one additional supplement (total 5 issues). The IJP publishes original work in all the fields of psychiatry. All papers are peer-reviewed before publication.
The issues are published Bimonthly. An additional supplement is also published annually. Articles can be submitted online from www.journalonweb.com . The journal provides immediate free access to all the published articles. The journal does not charge the authors for submission, processing or publication of the articles.
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