使用全自动平台诊断阿尔茨海默病血浆生物标志物的性能：一项真实世界的临床研究

IF 3.1 3区医学 Q2 NEUROSCIENCES Journal of Alzheimer's Disease Pub Date : 2025-11-01 Epub Date: 2025-01-26 DOI:10.1177/13872877241313145

Fausto Roveta, Elisa Rubino, Andrea Marcinnò, Alberto Grassini, Elisa Maria Piella, Fabio Ferrandes, Lucrezia Bonino, Giulia Giaracuni, Silvia Boschi, Giulia Gioiello, Selene Limoncelli, Aurora Cermelli, Chiara Lombardo, Giulio Mengozzi, Innocenzo Rainero

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引用次数: 0

摘要

本研究使用自动化平台评估了血浆生物标志物对阿尔茨海默病（AD）的诊断性能。在74名连续患者的队列中，AD患者血浆p-Tau181水平明显高于非AD组，并与脑脊液生物标志物相关。血浆p-Tau181对AD的诊断准确率较高，曲线下面积为0.854。研究结果表明，血浆生物标志物，特别是p-Tau181，可以提高临床诊断AD的可及性和效率，为传统方法提供了一种侵入性更小、成本效益更高的替代方法。

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Diagnostic performance of plasma biomarkers for Alzheimer's disease using a fully automated platform: A real-world clinical study.

This study evaluated the diagnostic performance of plasma biomarkers for Alzheimer's disease (AD) using an automated platform. In a cohort of 74 consecutive patients, plasma p-Tau181 levels were significantly higher in AD compared to non-AD groups and showed correlation with cerebrospinal fluid biomarkers. Plasma p-Tau181 demonstrated high diagnostic accuracy for AD, with an area under the curve of 0.854. The findings suggest that plasma biomarkers, particularly p-Tau181, could improve the accessibility and efficiency of AD diagnostics in clinical settings, offering a less invasive and cost-effective alternative to traditional methods.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.