Efficiency of indocyanine green fluorescence assisted laparoscopic hepatectomy in patients with hepatocellular carcinoma.

Objective: To analyze the efficacy of indocyanine green fluorescence (ICG-F)-assisted laparoscopic hepatectomy in patients with hepatocellular carcinoma (HCC).

Methods: This retrospective study included 120 patients with HCC who underwent laparoscopic hepatectomy in The First Affiliated Hospital of Soochow University from February 2020 to November 2022. Among them, 58 patients underwent conventional laparoscopic surgery (laparoscopic group), and 62 patients underwent ICG-F assisted laparoscopic surgery (ICG-F group). The perioperative conditions, levels of inflammatory factors before and after the operation, levels of liver function indexes, and incidence of complications in the two groups were statistically analyzed.

Results: The perioperative indexes of patients in the ICG-F group improved compared to the laparoscopic group (P<0.05). On the second day after the operation, the inflammatory response in the two groups was significantly higher than before the operation and significantly lower in the ICG-F group compared to the laparoscopic group (P<0.05). Liver function of the two groups decreased two days after the surgery and was markedly lower in the ICG-F group than the laparoscopic group (P<0.05). The incidence of complications in the ICG-F group was significantly lower than that in the laparoscopic group (P<0.05).

Conclusions: Compared with conventional laparoscopic surgery, ICG-F-assisted laparoscopic hepatectomy for HCC can reduce surgical injury, alleviate the degree of inflammatory response, protect patients' liver function, and significantly reduce the risk of complications.