Mohammad Abdurrehman Sheikh , Michelle P. Moon , Clinton B. Wright , Jose Gutierrez , Minghua Liu , Tatjana Rundek , Ken Cheung , Mady Hornig , Mitchell S.V. Elkind
{"title":"多重免疫标记与认知障碍和痴呆的关联：北曼哈顿研究","authors":"Mohammad Abdurrehman Sheikh , Michelle P. Moon , Clinton B. Wright , Jose Gutierrez , Minghua Liu , Tatjana Rundek , Ken Cheung , Mady Hornig , Mitchell S.V. Elkind","doi":"10.1016/j.bbih.2024.100937","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To determine whether a panel of immune markers adds significant information to known correlates of risk of dementia and cognitive impairment.</div></div><div><h3>Background</h3><div>The impact of immune mechanisms on dementia risk is incompletely characterized.</div></div><div><h3>Design/methods</h3><div>A subsample of the Northern Manhattan Study, a prospective cohort study in the racially/ethnically diverse population of New York City, underwent comprehensive neuropsychological testing up to three times, at approximately 5-year intervals. Cognitive outcomes were adjudicated as no cognitive impairment, mild cognitive impairment (MCI), or dementia. Immune markers were assessed using a multiplex immunoassay on plasma samples collected at the time of the first neuropsychological test. Least absolute shrinkage and selection operator (LASSO) techniques were employed to yield a panel of immune markers linearly related to the outcome of dementia/MCI vs. no cognitive impairment. Nested logistic regression models were run to determine the independent association of the immune marker panel with dementia/MCI after adjusting for other predictors of risk.</div></div><div><h3>Results</h3><div>Among 1179 participants (mean age 70.0 ± 8.9 years, 60% women, 68% Hispanic), immune markers improved model fit above demographic and vascular risk factors (p-value for likelihood ratio test <0.0001) as correlates of MCI/dementia. Individual immune markers found to be associated with dementia/MCI were C-X-C Motif Chemokine Ligand 9 (CXCL9) and C-C Motif Chemokine Ligand 2 (CCL2). The effect of the immune markers was comparable to traditional risk factors, with CCL2 (per SD) having almost the same effect as 1 year of aging and CXCL9 (per SD) showing approximately twice this magnitude.</div></div><div><h3>Conclusion</h3><div>Immune markers are associated with cognitive decline and dementia outcomes in a multi-ethnic cohort. More work is needed to further characterize these associations and determine therapeutic strategies. (Funded by the National Institute of Health/National Institute of Neurological Disorders and Stroke; grant number R01 29993 (Sacco/Elkind)).</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"43 ","pages":"Article 100937"},"PeriodicalIF":3.5000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757223/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of a multiplex immune marker panel with incident cognitive impairment and dementia: The Northern Manhattan Study\",\"authors\":\"Mohammad Abdurrehman Sheikh , Michelle P. Moon , Clinton B. Wright , Jose Gutierrez , Minghua Liu , Tatjana Rundek , Ken Cheung , Mady Hornig , Mitchell S.V. Elkind\",\"doi\":\"10.1016/j.bbih.2024.100937\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>To determine whether a panel of immune markers adds significant information to known correlates of risk of dementia and cognitive impairment.</div></div><div><h3>Background</h3><div>The impact of immune mechanisms on dementia risk is incompletely characterized.</div></div><div><h3>Design/methods</h3><div>A subsample of the Northern Manhattan Study, a prospective cohort study in the racially/ethnically diverse population of New York City, underwent comprehensive neuropsychological testing up to three times, at approximately 5-year intervals. Cognitive outcomes were adjudicated as no cognitive impairment, mild cognitive impairment (MCI), or dementia. Immune markers were assessed using a multiplex immunoassay on plasma samples collected at the time of the first neuropsychological test. Least absolute shrinkage and selection operator (LASSO) techniques were employed to yield a panel of immune markers linearly related to the outcome of dementia/MCI vs. no cognitive impairment. Nested logistic regression models were run to determine the independent association of the immune marker panel with dementia/MCI after adjusting for other predictors of risk.</div></div><div><h3>Results</h3><div>Among 1179 participants (mean age 70.0 ± 8.9 years, 60% women, 68% Hispanic), immune markers improved model fit above demographic and vascular risk factors (p-value for likelihood ratio test <0.0001) as correlates of MCI/dementia. Individual immune markers found to be associated with dementia/MCI were C-X-C Motif Chemokine Ligand 9 (CXCL9) and C-C Motif Chemokine Ligand 2 (CCL2). The effect of the immune markers was comparable to traditional risk factors, with CCL2 (per SD) having almost the same effect as 1 year of aging and CXCL9 (per SD) showing approximately twice this magnitude.</div></div><div><h3>Conclusion</h3><div>Immune markers are associated with cognitive decline and dementia outcomes in a multi-ethnic cohort. More work is needed to further characterize these associations and determine therapeutic strategies. 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Association of a multiplex immune marker panel with incident cognitive impairment and dementia: The Northern Manhattan Study
Objective
To determine whether a panel of immune markers adds significant information to known correlates of risk of dementia and cognitive impairment.
Background
The impact of immune mechanisms on dementia risk is incompletely characterized.
Design/methods
A subsample of the Northern Manhattan Study, a prospective cohort study in the racially/ethnically diverse population of New York City, underwent comprehensive neuropsychological testing up to three times, at approximately 5-year intervals. Cognitive outcomes were adjudicated as no cognitive impairment, mild cognitive impairment (MCI), or dementia. Immune markers were assessed using a multiplex immunoassay on plasma samples collected at the time of the first neuropsychological test. Least absolute shrinkage and selection operator (LASSO) techniques were employed to yield a panel of immune markers linearly related to the outcome of dementia/MCI vs. no cognitive impairment. Nested logistic regression models were run to determine the independent association of the immune marker panel with dementia/MCI after adjusting for other predictors of risk.
Results
Among 1179 participants (mean age 70.0 ± 8.9 years, 60% women, 68% Hispanic), immune markers improved model fit above demographic and vascular risk factors (p-value for likelihood ratio test <0.0001) as correlates of MCI/dementia. Individual immune markers found to be associated with dementia/MCI were C-X-C Motif Chemokine Ligand 9 (CXCL9) and C-C Motif Chemokine Ligand 2 (CCL2). The effect of the immune markers was comparable to traditional risk factors, with CCL2 (per SD) having almost the same effect as 1 year of aging and CXCL9 (per SD) showing approximately twice this magnitude.
Conclusion
Immune markers are associated with cognitive decline and dementia outcomes in a multi-ethnic cohort. More work is needed to further characterize these associations and determine therapeutic strategies. (Funded by the National Institute of Health/National Institute of Neurological Disorders and Stroke; grant number R01 29993 (Sacco/Elkind)).
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