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IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-01-25 DOI:10.1002/hed.28084

Maxime Henrion, Valérie Costes-Martineau, Ignacio González Bravo, Nathalie Boulle, Jérôme Solassol, Julie Vendrell, Renaud Garrel, Aude Trinquet, Vanessa Lacheretz-Szablewski

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引用次数: 0

摘要

背景：鼻窦鳞状细胞癌（SNSCC）中致癌人类乳头瘤病毒（HPV）的检出率因研究而异。对鼻窦鳞状细胞癌突变情况的研究仍然很少：方法：我们使用免疫组化、聚合酶链反应和原位杂交技术，根据 p16 蛋白表达、HPV-DNA 检测和 E6/E7 mRNA 表达，调查了 HPV 感染的流行率和预后意义。此外，我们还利用新一代测序技术评估了59名患者的基因突变情况：结果：1/3的SNSCC是真正的致癌型HPV驱动肿瘤，与非角化形态相关（p = 0.01），与预后无关。检测到以下基因突变：TP53、PIK3CA、CDKN2A、表皮生长因子受体和表皮生长因子受体 3。这些基因突变有的单独发生，有的与致癌 HPV 共同发生，有的与致癌 HPV 共同发生：结论：三分之一的SNSCC是高危HPV驱动的病变。然而，基因突变和HR-HPV感染并不相互排斥。需要进一步研究分析这些关联的预后价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Oncogenic Human Papillomaviruses Drive One-Third of Sinonasal Squamous Cell Carcinoma and Are Not Mutually Exclusive for Gene Mutations.

Background: The detection rate of oncogenic human papillomaviruses (HPVs) in sinonasal squamous cell carcinomas (SNSCCs) varies among studies. The mutational landscape of SNSCCs remains poorly investigated.

Methods: We investigated the prevalence and prognostic significance of HPV infections based on p16 protein expression, HPV-DNA detection, and E6/E7 mRNA expression using immunohistochemistry, polymerase chain reaction, and in situ hybridization, respectively. In addition, we evaluated the genetic mutations in 59 patients using next-generation sequencing.

Results: One-third of the SNSCCs were truly oncogenic HPV-driven tumors associated with a nonkeratinizing morphology (p = 0.01) and did not correlate with the prognosis. The following gene mutations were detected: TP53, PIK3CA, CDKN2A, EGFR, and FGFR3. These mutations occurred alone, in association with, or with oncogenic HPV.

Conclusion: One-third of SNSCCs were high-risk HPV driven lesions. However, gene mutations and HR-HPV infections are not mutually exclusive. Further studies are required to analyze the prognostic value of these associations.

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.

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