Eosinophilic dermatitis in a patient with chronic lymphocytic leukemia.

Abstract: Hematological malignancies are known to have cutaneous manifestations, either in the form of direct infiltration of skin by malignant cells or as a result of paraneoplastic syndrome. Many hematological malignancies, including chronic lymphocytic leukemia (CLL), are known to cause malignancy-induced Eosinophilic Dermatoses. We present a case of an elderly woman who presented with multiple pruritic patches. On clinical examination, the patient had multiple enlarged lymph nodes in the cervical and inguinal regions. The total leucocyte count was elevated and peripheral blood examination showed atypical lymphocytes. Flow cytometry was suggestive of CLL. The skin biopsy was suggestive of Eosinophilic Dermatoses in a case of chronic lymphocytic leukemia. We should be aware of this entity as they mimic insect bites, urticaria, and other skin conditions both histologically and clinically and to avoid a diagnostic pitfall.