Emilie Olié, Guillaume Clain, Manon Malestroit, Dimitri Fiedos, Fabrice Cognasse, Jeremy Deverdun, Emmanuelle Le Bars, Philippe Courtet
{"title":"重度抑郁症患者的自杀状态、炎症标志物、静息状态功能活动和连接性之间的关系","authors":"Emilie Olié, Guillaume Clain, Manon Malestroit, Dimitri Fiedos, Fabrice Cognasse, Jeremy Deverdun, Emmanuelle Le Bars, Philippe Courtet","doi":"10.4088/JCP.23m15148","DOIUrl":null,"url":null,"abstract":"<p><p></p><p><p><b>Abstract</b>.</p><p><p><b>Background:</b> This study aimed to identify (1) neural markers of suicide attempt using resting-state functional magnetic resonance imaging (rs-fMRI) and (2) associations between rs-fMRI metrics and resting-state functional connectivity (rs-FC), suicidal phenotype, and peripheral blood inflammation markers.</p><p><p><b>Methods:</b> Inflammation markers (C-reactive protein [CRP], interleukin [IL]-1β, IL-2, and IL-6, and tumor necrosis factor-α TNF-α) and rs-fMRI metrics were measured in 20 healthy controls (HCs) and 42 patients with unipolar depression according to the <i>DSM-5</i> criteria (n = 21 suicide attempters [SAs] in the last 8 days and n = 21 affective controls [ACs] without lifetime suicidal history) between February 1 and November 30, 2017. Amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), voxel-mirrored homotopic connectivity, and rs-FC were estimated in prefrontal cortex, anterior cingulate cortex, and insula.</p><p><p><b>Results:</b> Participants were mainly women (age: 40-48 years). Only CRP concentration was higher in SAs than in ACs and HCs (3.55 [0.5; 13.3] vs 0.6 [0.3; 4.4] vs 0.8 [0.3; 13.9] mg/L, respectively, <i>P</i> < 10<sup>-3</sup>). ALFF values in the pars opercularis of the inferior frontal gyrus (IFG) were lower in SAs than in ACs and HCs (all <i>P</i> < 10<sup>-2</sup>), even after controlling for suicidal ideation intensity and CRP level. Suicidal ideation was negatively correlated with all rs-fMRI metrics (except ReHo of left side) of this region in patients. The rs-FC values of bilateral anterior cingulate cortex, left orbital IFG, and middle frontal orbital gyrus were higher in SAs than in ACs and HCs (all <i>P</i> < .05).</p><p><p><b>Conclusions:</b> Resting-state activity and connectivity in regions involved in language, cognitive control, and decision making may be associated with suicidal behaviors, but not with inflammation markers.</p><p><p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT03052855.</p>","PeriodicalId":50234,"journal":{"name":"Journal of Clinical Psychiatry","volume":"85 3","pages":""},"PeriodicalIF":4.5000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of Suicidal Status, Inflammation Markers, and Resting-State Functional Activity and Connectivity in Patients With Major Depressive Disorder.\",\"authors\":\"Emilie Olié, Guillaume Clain, Manon Malestroit, Dimitri Fiedos, Fabrice Cognasse, Jeremy Deverdun, Emmanuelle Le Bars, Philippe Courtet\",\"doi\":\"10.4088/JCP.23m15148\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p></p><p><p><b>Abstract</b>.</p><p><p><b>Background:</b> This study aimed to identify (1) neural markers of suicide attempt using resting-state functional magnetic resonance imaging (rs-fMRI) and (2) associations between rs-fMRI metrics and resting-state functional connectivity (rs-FC), suicidal phenotype, and peripheral blood inflammation markers.</p><p><p><b>Methods:</b> Inflammation markers (C-reactive protein [CRP], interleukin [IL]-1β, IL-2, and IL-6, and tumor necrosis factor-α TNF-α) and rs-fMRI metrics were measured in 20 healthy controls (HCs) and 42 patients with unipolar depression according to the <i>DSM-5</i> criteria (n = 21 suicide attempters [SAs] in the last 8 days and n = 21 affective controls [ACs] without lifetime suicidal history) between February 1 and November 30, 2017. Amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), voxel-mirrored homotopic connectivity, and rs-FC were estimated in prefrontal cortex, anterior cingulate cortex, and insula.</p><p><p><b>Results:</b> Participants were mainly women (age: 40-48 years). Only CRP concentration was higher in SAs than in ACs and HCs (3.55 [0.5; 13.3] vs 0.6 [0.3; 4.4] vs 0.8 [0.3; 13.9] mg/L, respectively, <i>P</i> < 10<sup>-3</sup>). ALFF values in the pars opercularis of the inferior frontal gyrus (IFG) were lower in SAs than in ACs and HCs (all <i>P</i> < 10<sup>-2</sup>), even after controlling for suicidal ideation intensity and CRP level. Suicidal ideation was negatively correlated with all rs-fMRI metrics (except ReHo of left side) of this region in patients. The rs-FC values of bilateral anterior cingulate cortex, left orbital IFG, and middle frontal orbital gyrus were higher in SAs than in ACs and HCs (all <i>P</i> < .05).</p><p><p><b>Conclusions:</b> Resting-state activity and connectivity in regions involved in language, cognitive control, and decision making may be associated with suicidal behaviors, but not with inflammation markers.</p><p><p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT03052855.</p>\",\"PeriodicalId\":50234,\"journal\":{\"name\":\"Journal of Clinical Psychiatry\",\"volume\":\"85 3\",\"pages\":\"\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2024-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4088/JCP.23m15148\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4088/JCP.23m15148","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Association of Suicidal Status, Inflammation Markers, and Resting-State Functional Activity and Connectivity in Patients With Major Depressive Disorder.
Abstract.
Background: This study aimed to identify (1) neural markers of suicide attempt using resting-state functional magnetic resonance imaging (rs-fMRI) and (2) associations between rs-fMRI metrics and resting-state functional connectivity (rs-FC), suicidal phenotype, and peripheral blood inflammation markers.
Methods: Inflammation markers (C-reactive protein [CRP], interleukin [IL]-1β, IL-2, and IL-6, and tumor necrosis factor-α TNF-α) and rs-fMRI metrics were measured in 20 healthy controls (HCs) and 42 patients with unipolar depression according to the DSM-5 criteria (n = 21 suicide attempters [SAs] in the last 8 days and n = 21 affective controls [ACs] without lifetime suicidal history) between February 1 and November 30, 2017. Amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), voxel-mirrored homotopic connectivity, and rs-FC were estimated in prefrontal cortex, anterior cingulate cortex, and insula.
Results: Participants were mainly women (age: 40-48 years). Only CRP concentration was higher in SAs than in ACs and HCs (3.55 [0.5; 13.3] vs 0.6 [0.3; 4.4] vs 0.8 [0.3; 13.9] mg/L, respectively, P < 10-3). ALFF values in the pars opercularis of the inferior frontal gyrus (IFG) were lower in SAs than in ACs and HCs (all P < 10-2), even after controlling for suicidal ideation intensity and CRP level. Suicidal ideation was negatively correlated with all rs-fMRI metrics (except ReHo of left side) of this region in patients. The rs-FC values of bilateral anterior cingulate cortex, left orbital IFG, and middle frontal orbital gyrus were higher in SAs than in ACs and HCs (all P < .05).
Conclusions: Resting-state activity and connectivity in regions involved in language, cognitive control, and decision making may be associated with suicidal behaviors, but not with inflammation markers.
期刊介绍：
For over 75 years, The Journal of Clinical Psychiatry has been a leading source of peer-reviewed articles offering the latest information on mental health topics to psychiatrists and other medical professionals.The Journal of Clinical Psychiatry is the leading psychiatric resource for clinical information and covers disorders including depression, bipolar disorder, schizophrenia, anxiety, addiction, posttraumatic stress disorder, and attention-deficit/hyperactivity disorder while exploring the newest advances in diagnosis and treatment.
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