微波辅助[3 + 2]环氧二氰与苄基Meldrum酸的环加成反应。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC Organic & Biomolecular Chemistry Pub Date : 2025-03-24 Epub Date: 2025-01-24 DOI:10.1039/d4ob01702a

Yazdanbakhsh Lotfi Nosood , Negin Fattahi Ghahnavieh , Ahmad Takallou , Ali Rostami , Amirhossein Ebrahimi , Muhammad U. Anwar , Ahmed Al-Harrasi

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引用次数: 0

摘要

研究了在微波辐射和无溶剂条件下，二氰环氧化合物与苄基Meldrum's酸[3 + 2]环加成合成三恶螺十二烷。这种方法提出了一个高度非立体和区域选择性的路线，提供类似的立体选择性传统回流在甲苯，但具有较短的反应时间和提高产量。

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Microwave-assisted [3 + 2] cycloaddition reactions of dicyanoepoxides with benzylidene Meldrum's acids†

The [3 + 2] cycloaddition of dicyanoepoxides with benzylidene Meldrum's acid under microwave irradiation and solvent-free conditions was explored for the synthesis of trioxaspirodecanes. This method presents a highly diastereo- and regioselective route to spiro cycloadducts, delivering similar stereoselectivity to conventional reflux in toluene but with shorter reaction times and improved yields.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.