Zhiyuan Ma , Hu Wang , Zhengxing Zhou , Chengli Lu , Minglin Zhang , Renmin Mu , Chengmin Zhang , Zhiqiang Yi , Zilin Deng , Yingying Zhao , Jiaxing Zhu , Guorong Wen , Hai Jin , Jiaxing An , Biguang Tuo , Peng Yuan , Xuemei Liu , Taolang Li
{"title":"SLC26A9通过激活PI3K/AKT信号通路促进乳腺癌的发生和发展。","authors":"Zhiyuan Ma , Hu Wang , Zhengxing Zhou , Chengli Lu , Minglin Zhang , Renmin Mu , Chengmin Zhang , Zhiqiang Yi , Zilin Deng , Yingying Zhao , Jiaxing Zhu , Guorong Wen , Hai Jin , Jiaxing An , Biguang Tuo , Peng Yuan , Xuemei Liu , Taolang Li","doi":"10.1016/j.bbamcr.2025.119912","DOIUrl":null,"url":null,"abstract":"<div><div>SLC26A9 is a member of the Slc26a family of multifunctional anion transporters that function as Cl<sup>−</sup> channels in the stomach. We reported for the first time that SLC26A9 is involved in gastric tumorigenesis. However, the role of SLC26A9 in breast cancer has not yet been investigated. We first demonstrated that the upregulation of SLC26A9 is associated with the clinicopathological progression and poor prognosis of patients with breast cancer and is positively correlated with HER2 amplification. SLC26A9 alters the proliferation, migration, and invasion potential of breast cancer cells by regulating the PI3K/AKT signaling pathway. SLC26A9 acts as an oncogene in the development of breast cancer. These findings provide valuable insights for the development of future diagnostic and therapeutic strategies for BC.</div></div>","PeriodicalId":8754,"journal":{"name":"Biochimica et biophysica acta. Molecular cell research","volume":"1872 3","pages":"Article 119912"},"PeriodicalIF":3.7000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SLC26A9 promotes the initiation and progression of breast cancer by activating the PI3K/AKT signaling pathway\",\"authors\":\"Zhiyuan Ma , Hu Wang , Zhengxing Zhou , Chengli Lu , Minglin Zhang , Renmin Mu , Chengmin Zhang , Zhiqiang Yi , Zilin Deng , Yingying Zhao , Jiaxing Zhu , Guorong Wen , Hai Jin , Jiaxing An , Biguang Tuo , Peng Yuan , Xuemei Liu , Taolang Li\",\"doi\":\"10.1016/j.bbamcr.2025.119912\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>SLC26A9 is a member of the Slc26a family of multifunctional anion transporters that function as Cl<sup>−</sup> channels in the stomach. We reported for the first time that SLC26A9 is involved in gastric tumorigenesis. However, the role of SLC26A9 in breast cancer has not yet been investigated. We first demonstrated that the upregulation of SLC26A9 is associated with the clinicopathological progression and poor prognosis of patients with breast cancer and is positively correlated with HER2 amplification. SLC26A9 alters the proliferation, migration, and invasion potential of breast cancer cells by regulating the PI3K/AKT signaling pathway. SLC26A9 acts as an oncogene in the development of breast cancer. These findings provide valuable insights for the development of future diagnostic and therapeutic strategies for BC.</div></div>\",\"PeriodicalId\":8754,\"journal\":{\"name\":\"Biochimica et biophysica acta. Molecular cell research\",\"volume\":\"1872 3\",\"pages\":\"Article 119912\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et biophysica acta. Molecular cell research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0167488925000175\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/27 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et biophysica acta. Molecular cell research","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167488925000175","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/27 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
SLC26A9 promotes the initiation and progression of breast cancer by activating the PI3K/AKT signaling pathway
SLC26A9 is a member of the Slc26a family of multifunctional anion transporters that function as Cl− channels in the stomach. We reported for the first time that SLC26A9 is involved in gastric tumorigenesis. However, the role of SLC26A9 in breast cancer has not yet been investigated. We first demonstrated that the upregulation of SLC26A9 is associated with the clinicopathological progression and poor prognosis of patients with breast cancer and is positively correlated with HER2 amplification. SLC26A9 alters the proliferation, migration, and invasion potential of breast cancer cells by regulating the PI3K/AKT signaling pathway. SLC26A9 acts as an oncogene in the development of breast cancer. These findings provide valuable insights for the development of future diagnostic and therapeutic strategies for BC.
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BBA Molecular Cell Research focuses on understanding the mechanisms of cellular processes at the molecular level. These include aspects of cellular signaling, signal transduction, cell cycle, apoptosis, intracellular trafficking, secretory and endocytic pathways, biogenesis of cell organelles, cytoskeletal structures, cellular interactions, cell/tissue differentiation and cellular enzymology. Also included are studies at the interface between Cell Biology and Biophysics which apply for example novel imaging methods for characterizing cellular processes.
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