从基因组数据集快速识别端粒重复序列的工具包。

Max R Brown, Pablo Manuel Gonzalez de La Rosa, Mark Blaxter
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摘要

摘要:tidk(端粒识别工具包的缩写)使用一种简单,快速的算法来扫描长DNA读取,以寻找运行中短串联重复DNA的存在,并根据规范的DNA字符串表示将它们聚集起来。这些是端粒重复序列候选者。我们的算法在已知端粒重复单位的基因组中被证明是准确的,并在各种新组装的基因组中进行了测试,以发现新的端粒重复单位。工具提供了鉴定端粒重复从头,扫描基因组已知的端粒重复,并可视化端粒重复在组装。tidk是在Rust中实现的,它是一个命令行工具,可以使用Rust工具链进行编译,也可以从bioconda下载二进制文件。可用性:tidk Rust crate在MIT许可下免费提供(https://crates.io/crates/tidk),源代码可在https://github.com/tolkit/telomeric-identifier.Supplementary获取:补充数据可在Bioinformatics在线获取。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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tidk: a toolkit to rapidly identify telomeric repeats from genomic datasets.

Summary: "tidk" (short for telomere identification toolkit) uses a simple, fast algorithm to scan long DNA reads for the presence of short tandemly repeated DNA in runs, and to aggregate them based on canonical DNA string representation. These are telomeric repeat candidates. Our algorithm is shown to be accurate in genomes for which the telomeric repeat unit is known and is tested across a wide variety of newly assembled genomes to uncover new telomeric repeat units. Tools are provided to identify telomeric repeats de novo, scan genomes for known telomeric repeats, and to visualize telomeric repeats on the assembly. "tidk" is implemented in Rust and is available as a command line tool which can be compiled using the Rust toolchain or downloaded as a binary from bioconda.

Availability and implementation: The "tidk" Rust crate is freely available under the MIT license (https://crates.io/crates/tidk), and the source code is available at https://github.com/tolkit/telomeric-identifier.

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