肝移植后非亲属骨髓移植治疗慢性髓系白血病。

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Internal Medicine Pub Date : 2025-08-01 Epub Date: 2025-02-01 DOI:10.2169/internalmedicine.4759-24

Mirea Watanabe, Atsushi Marumo, Daishi Onai, Meya Li, Yuta Kaito, Toshio Asayama, Shunsuke Yui, Yasunobu Nagata, Satoshi Wakita, Hiroki Yamaguchi

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摘要

本报告描述了一例29岁的慢性髓性白血病患者，在活体肝移植后接受了造血干细胞移植（HSCT）。供体选择，调理方案，和移植物抗宿主病（GVHD）预防进行了讨论。患者接受非清髓调理方案和ABO血型匹配的非相关人白细胞抗原完全匹配的供者。免疫抑制剂他克莫司和霉酚酸酯被用于预防GVHD。波纳替尼维持治疗有效地维持了缓解。该病例强调了实体器官移植后处理HSCT的复杂性，并为未来的病例提出了策略。

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Unrelated Bone Marrow Transplantation for Chronic Myeloid Leukemia after Liver Transplantation.

This report describes the case of a 29-year-old patient with chronic myeloid leukemia in the blast phase who underwent hematopoietic stem cell transplantation (HSCT) after living-donor liver transplantation. Donor selection, conditioning regimens, and graft-versus-host disease (GVHD) prophylaxis are discussed. The patient received a non-myeloablative conditioning regimen and ABO blood group-matched unrelated human leukocyte antigen fully-matched donors. Immunosuppressants tacrolimus and mycophenolate mofetil were administered to prevent GVHD. Maintenance therapy with ponatinib effectively maintained remission. This case highlights the complexities of managing HSCT after solid organ transplantation and suggests strategies for future cases.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.