Xiaorui Zhang , Jie Zhao , Qichang Yang , Zhangxuan Chen , Haifeng Wang , Shuang-Xi Gu , Jian Lv
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Trimethylsulfoxonium iodide: a green methylating agent for site-selective methylation of carbohydrates†
Partial methylation of hydroxyl groups plays a crucial role in structural modification, functional optimization, and bioactivity regulation of carbohydrate compounds. Despite its significance, research in this field remains scarce. Furthermore, traditional methylating reagents are frequently associated with toxicity and environmental pollution issues. Herein, we report the application of trimethylsulfonium iodide [(CH3)3S(O)I] as a green and efficient methylating agent for the methylation of carbohydrate substrates. By combining (CH3)3S(O)I with an efficient iron catalytic system, we achieved site selectivity and high yield in the reaction.
期刊介绍：
Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.
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