Jin Chai
(, ), Changzhen Qu
(, ), Kunpeng Li
(, ), Jiaheng Liang
(, ), Qian Zhou
(, ), Rong Zhuang
(, ), Shuo Wang
(, ), Fei Xu
(, ), Qingyan Jia
(, ), Peng Li
(, )
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Yolk–shell Au@carbon nanospheres with photothermal and electron-plunder sterilization for infected wound healing
Highly pathogenic-resistant bacteria infections seriously hinder the wound healing process and induce a catastrophic threat to human health. Incorporating multiple antibacterial strategies into nanostructured materials has been verified to possess paramount promise for ameliorating therapeutic efficiency against resistant bacteria. Herein, a multifunctional yolk–shell nanocomposite (Au@HCN) comprised of an aurum (Au) core and hollow carbon nanosphere (HCN) shell was prepared via one-step copolymerization and carbonization. The electron plunder by Au@HCN on the bacterial membrane leads to bacterial membrane depolarization and enhanced reactive oxygen species (ROS) metabolism, resulting in remarkable efficacy against drug-resistant bacteria under dark conditions. Moreover, the synergetic photothermal therapy (PTT) displayed significant antibacterial properties (∼98%) when exposed to near-infrared (NIR) irradiation in vitro. Meanwhile, efficient eradication of drug-resistant bacteria in the infected wound in vivo was observed under NIR exposure, thereby promoting wound healing through the prominent antibacterial properties of Au@HCN. The yolk–shell Au@HCN possesses tremendous potential for combating multidrug resistance with high efficiency.
期刊介绍：
Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.
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