用于可持续合成药物和手性有机构件的脂肪酶

IF 5.6 3区材料科学 Q2 GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY Advanced Sustainable Systems Pub Date : 2025-01-17 Epub Date: 2024-10-09 DOI:10.1002/adsu.202400495

Moumita Khanra, V. Ravichandiran, Sharada Prasanna Swain

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引用次数: 0

摘要

生物催化是一种绿色可持续的合成手性有机构件和活性药物成分（API）的方法。联合国2030年可持续发展目标倡导工业使用绿色、可持续、可回收的化学品来减少环境污染。制药公司正在采用生物催化技术来制造手性活性药物成分。脂肪酶催化的动力学和动态动力学拆分法是药学上公认的制备手性原料药的方法。本文综述了近十年来脂肪酶合成手性API/KSM分子的研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Lipase Enzymes for Sustainable Synthesis of Pharmaceuticals and Chiral Organic Building Blocks

Biocatalysis is a green and sustainable process for synthesizing chiral organic building blocks and active pharmaceutical ingredients (API). United Nations' Sustainable Development Goals 2030 advocates using green, sustainable, recyclable chemicals by industries to reduce environmental pollution. Pharmaceutical companies are adopting biocatalysis technologies for manufacturing chiral active pharmaceutical ingredients. The lipase-catalyzed kinetic and dynamic-kinetic resolution method is a pharmaceutically accepted process for manufacturing chiral API. This review describes the reported methods for synthesizing chiral API/KSM (Key Starting Material) molecules using lipase enzymes over the last ten years.

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来源期刊

Advanced Sustainable Systems Environmental Science-General Environmental Science

CiteScore

10.80

自引率

4.20%

发文量

186

期刊介绍： Advanced Sustainable Systems, a part of the esteemed Advanced portfolio, serves as an interdisciplinary sustainability science journal. It focuses on impactful research in the advancement of sustainable, efficient, and less wasteful systems and technologies. Aligned with the UN's Sustainable Development Goals, the journal bridges knowledge gaps between fundamental research, implementation, and policy-making. Covering diverse topics such as climate change, food sustainability, environmental science, renewable energy, water, urban development, and socio-economic challenges, it contributes to the understanding and promotion of sustainable systems.