年龄相关性黄斑变性的肠道微生物失调

IF 2.8 3区医学 Q1 OPHTHALMOLOGY Acta Ophthalmologica Pub Date : 2025-01-19 DOI:10.1111/aos.17311

Joëlle Vergroesen, Jeroen Vermeulen, Eric Thee, Bart Liefers, Caroline Klaver

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引用次数: 0

摘要

目的：肠道微生物群在炎症性疾病中具有重要影响。多项研究表明，肠道微生物群与年龄相关性黄斑变性（AMD）之间存在联系。然而，没有一致的分类群报道。方法：我们纳入了来自鹿特丹研究（RS）的1372名受试者。AMD的特征（如网状伪结节、视网膜色素上皮变性和色素沉着）由人眼眼底彩色照片分级。然后，通过深度学习分割模型自动量化这些特征的区域。根据RS分级确定分期（前期= 239，早中期= 75，晚期= 6）。对年龄、性别和BMI进行倾向评分匹配。使用零调整模型评估与分类学和功能特征的多变量关联(MaAsLin2；复合泊松)。p值为假发现率调整后的值（q值）。分类群相关（q < 0.25）与7个AMD（相关）结果中至少2个相关。结果：我们没有观察到与α或β多样性的关联。19个类群与AMD相关，其中7个类群在进一步调整饮食数据后仍然存在。嗜木真杆菌群、Lachnoclostridium、Faecalibacterium、planchnicodoribacter和副芽孢杆菌（parabobacterides disasonis）与AMD表型相关。拟副杆菌和Akkermansia与AMD表型呈负相关。此外，46个MetaCyc通路与AMD相关，其中15个在对饮食数据进行额外调整后仍然存在。GLUCARDEG。PWY、PWY.5028、PWY.5347、PWY.5415、PWY.5532、PWY.5971、PWY.6969和TCA与AMD表型相关。FOLSYN。PWY LEU.DEG2。PWY,哑剧演员。PWY PANTOSYN。PWY0.1586和PYRIDNUCSYN。PWY与AMD表型呈负相关。结论：几种肠道微生物群与AMD表型相关。AMD的病理生理可能与肠道相关代谢途径的变化有关。

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Gut microbial dysbiosis in age-related macular degeneration

Purpose: The gut microbiome is highly influential in diseases with inflammatory components. Multiple studies showed a link between the gut microbiome and age-related macular degeneration (AMD). However, no consistent taxa have been reported.

Methods: We included 1372 participants from the Rotterdam Study (RS). AMD features (e.g. [reticular pseudo-]drusen, retinal pigment epithelium degeneration, and hyperpigmentation) were graded by human graders on color fundus photographs. Next, areas of these features were automatically quantified by a deep learning segmentation model. Stages were determined according to the RS classification (preliminary = 239, early-intermediate = 75, late = 6). Propensity score matching was performed on age, sex and BMI. Multivariable associations with taxonomic and functional profiles were assessed using zero-adjusted models (MaAsLin2; Compound Poisson). p-values were false discovery rate-adjusted (q-values). Taxa associated (q < 0.25) with at least two out of seven AMD(-related) outcomes are reported.

Results: We observed no associations with alpha- or beta-diversity. Nineteen taxa were associated with AMD, of which 7 persisted after additional adjustment for dietary data. Eubacterium xylanophilum group, Lachnoclostridium, Faecalibacterium, Odoribacter splanchnicus and Parabacteroides distasonis were associated with an AMD phenotype. Parabacteroides and Akkermansia were inversely associated with an AMD phenotype. Moreover, 46 MetaCyc pathways were associated with AMD, of which 15 persisted after additional adjustment for dietary data. GLUCARDEG.PWY, PWY.5028, PWY.5347, PWY.5415, PWY.5532, PWY.5971, PWY.6969 and TCA were associated with an AMD phenotype. FOLSYN.PWY, LEU.DEG2.PWY, PANTO.PWY, PANTOSYN.PWY, PWY.6612, PWY0.1586 and PYRIDNUCSYN.PWY were inversely associated with an AMD phenotype.

Conclusions: Several gut microbiota were associated with an AMD phenotype. AMD pathophysiology might be linked to changes in gut-related metabolic pathways.

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.