封面：南极假丝酵母脂肪酶A的蛋白质工程以提高叔醇的酯化（ChemBioChem 24/2024）

IF 2.8 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY ChemBioChem Pub Date : 2024-12-23 DOI:10.1002/cbic.202482401

Karla Wagner, Anke Hummel, Jianing Yang, Satoshi Horino, Kyohei Kanomata, Shuji Akai, Harald Gröger

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引用次数: 0

摘要

封面为南极念珠菌脂肪酶A的结构，背景为极光。就像大自然在天空中展示的光一样，酶有时会以意想不到的形式展现它们的力量，从而丰富了应用范围。通过对活性位点进行工程改造，可以进一步提高脂肪酶的催化性能，使酶开始以(R)叔醇的对映选择性酯化为代表的无限时空之旅，这是难以实现的。更多细节可以在第10.1002/ cic条中找到。202400082，作者：Shuji Akai， Harald Gröger及其同事。

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Front Cover: Protein Engineering of Lipase A from Candida Antarctica to Improve Esterification of Tertiary Alcohols (ChemBioChem 24/2024)

The front cover shows the structure of lipase A from Candida antarctica with auroras in the background. Like this light display of Nature in the sky, enzymes sometimes unfold their power in unexpected forms, thus enriching the scope of applications. By engineering the active site, the catalytic properties of the lipase can be further improved so that the enzyme begins its infinite journey through space and time typified by the enantioselective esterification of (R)-tertiary alcohols, which has been difficult to achieve. More details can be found in article 10.1002/cbic.202400082 by Shuji Akai, Harald Gröger, and co-workers.

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).