Versatile New Lanthanide Complexes Containing Organic Ligand Derived From Vitamin B6 as Potential Tyrosinase Inhibitors: Synthesis, Characterizations, and Structure Activity Investigations

The synthesis, characterizations, and tyrosinase enzyme inhibition experiments on eight novel lanthanide metal complexes (1–8) are reported. A multidonor versatile ligand L was prepared from the condensation reaction of picolinohydrazide with pyridoxal. The synthesized complexes were analyzed using FT-IR and UV-vis spectroscopies, elemental (CHN) analysis, and single-crystal X-ray diffraction analysis. These complexes exhibited significant tyrosinase enzyme inhibition with IC₅₀ values in the range of 9.67 ± 0.17–21.88 ± 0.57 μM. The molecular docking results of the most active complex (2) correlate well with in vitro observations.