From Bench to Clinic: Crosslinking Approaches for Next-Generation Collagen Fillers

With a deeper understanding of the aging process, injectable dermal fillers have revolutionized cosmetic dermatology and plastic surgery. These minimally invasive treatments address signs of aging, such as wrinkles, fine lines, and volume loss. The market for injectable dermal fillers expands yearly, with each product offering unique compositions that influence therapeutic outcomes, handling properties, and potential adverse effects. Fillers are generally classified into three major types: temporary, semi-permanent, and permanent. Temporary fillers, including hyaluronic acid (HA) and collagen (COL)-based options, provide reliable correction but typically have limited longevity. Semi-permanent and permanent fillers, made from synthetic materials like poly-L-lactic acid and polymethylmethacrylate (PMMA), offer extended durations of neocollagenesis. This review focuses specifically on COL-based fillers, discussing both FDA-approved products and those still in the research stage.