外周转录组学在SARS-CoV2感染急性和长期肾功能障碍中的作用。

IF 3 Q1 UROLOGY & NEPHROLOGY Kidney360 Pub Date : 2025-02-03 DOI:10.34067/KID.0000000727
Pushkala Jayaraman, Madhumitha Rajagopal, Ishan Paranjpe, Mayte Suarez-Farinas, Lora E Liharska, Ryan C Thompson, Diane Marie Del Valle, Noam D Beckmann, Anina N Lund, Pooja Gownivaripally, Wonsuk Oh, Faris F Gulamali, Justin Kauffman, Edgar Gonzalez-Kozlova, Sergio Dellepiane, George Vasquez-Rios, Akhil Vaid, Joy Jiang, Ben Fox, Ankit Sakhuja, Steven Chen, Ephraim Kenigsberg, John Cijiang He, Steven G Coca, Lili Chan, Miram Merad, Seunghee Kim-Schulze, Sacha Gnjatic, Ephraim L Tsalik, Raymond Langley, Alexander W Charney, Girish N Nadkarni
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引用次数: 0

摘要

背景:急性肾损伤(AKI)在SARS-CoV-2感染和COVID-19中很常见,常导致长期肾功能障碍。然而,AKI严重程度的转录组学特征及其长期影响尚未得到充分研究。方法:我们对住院SARS-CoV-2患者的外周血单个核细胞(PBMCs)进行了大量RNA测序,并与同一队列的蛋白质组学数据进行了补充。我们将功能富集结果与脓毒症aki的历史数据进行了比较,随后检查了分子特征与长期肾功能变化之间的关系。结果:283例患者中,57例为轻度AKI(1期),49例为重度AKI(2期或3期)。在调整了年龄、性别、感染严重程度和已有的慢性肾脏疾病(CKD)后,我们在重度AKI与对照组比较中发现了6432个差异表达基因(deg),在轻度AKI与对照组比较中发现了840个差异表达基因(deg),在重度AKI与对照组比较中发现了1213个差异表达基因(deg)。我们证明SARS-CoV-2感染的严重AKI与线粒体功能障碍和内质网应激有关。与败血症- aki的功能重叠提示潜在的更广泛的治疗适用性。长期肾功能不全受细胞能量代谢和免疫反应紊乱的影响。
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Peripheral Transcriptomics in Acute and Long-Term Kidney Dysfunction in SARS-CoV-2 Infection.
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来源期刊
Kidney360
Kidney360 UROLOGY & NEPHROLOGY-
CiteScore
3.90
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0.00%
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