Aycan Sıkı , Can Köse , Esin Kasap , Ebru Şahin Güleç , Ahmet Demir
{"title":"卵巢储备对无精子症患者接受体外受精治疗妊娠结局的影响","authors":"Aycan Sıkı , Can Köse , Esin Kasap , Ebru Şahin Güleç , Ahmet Demir","doi":"10.1016/j.rbmo.2024.104590","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Infertility is a condition that has been increasingly prevalent in recent years and has demographic, psychological, economic, and medical consequences in society. A review of the literature reveals a large number of studies conducted on azoospermia (AZO) and diminished ovarian reserve (DOR), but there are relatively few studies comparing these two conditions simultaneously. In our study, we aimed to contribute to the literature by comparing these two challenging groups that we treat in our clinic, both from the physician's and the patient's perspective.</div></div><div><h3>Materials and Methods</h3><div>In our study, patients diagnosed with azoospermia (AZO) and diminished ovarian reserve (DOR) who received intracytoplasmic sperm injection (ICSI) treatment at the Tepecik Training and Research Hospital, Department of Obstetrics and Gynecology, IVF Center, between January 1, 2017, and June 30, 2023, were examined. Within the inclusion and exclusion criteria, 100 cases were identified and divided into three groups based on treatment indications: AZO (n=34), DOR (n=34), and AZO+DOR (n=32). The patients' age, basal hormone levels (FSH, E2, PRG, AMH), treatment indications, embryo transfer days, and clinical pregnancy outcomes were documented.</div></div><div><h3>Results</h3><div>Clinical pregnancy rates were found to be 64.7% in the AZO group, 50% in the DOR group, and 34.4% in the DOR+AZO group. When the groups were compared among themselves, the clinical pregnancy rate in the AZO group was found to be significantly higher than in the DOR+AZO group (p=0.014). When comparing live birth rates among the groups, the live birth rate in the DOR+AZO group was found to be significantly lower than in the AZO group (p=0.022). When the types of pregnancies were examined among the groups, in the DOR group, pregnancies resulted in live births at a rate of 70.6% and in missed abortion at a rate of 29.4%.</div></div><div><h3>Conclusions</h3><div>Clinical pregnancy and live birth rates were found to be significantly higher in the AZO group compared to the DOR+AZO group. We believe that ovarian reserve in women is more determinant of IVF/ICSI success than sperm quality.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 ","pages":"Article 104590"},"PeriodicalIF":3.5000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"EFFECT OF OVARIAN RESERVE ON PREGNANCY OUTCOMES IN PATIENTS UNDERGOING IVF TREATMENT DUE TO AZOOSPERMIA\",\"authors\":\"Aycan Sıkı , Can Köse , Esin Kasap , Ebru Şahin Güleç , Ahmet Demir\",\"doi\":\"10.1016/j.rbmo.2024.104590\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>Infertility is a condition that has been increasingly prevalent in recent years and has demographic, psychological, economic, and medical consequences in society. A review of the literature reveals a large number of studies conducted on azoospermia (AZO) and diminished ovarian reserve (DOR), but there are relatively few studies comparing these two conditions simultaneously. In our study, we aimed to contribute to the literature by comparing these two challenging groups that we treat in our clinic, both from the physician's and the patient's perspective.</div></div><div><h3>Materials and Methods</h3><div>In our study, patients diagnosed with azoospermia (AZO) and diminished ovarian reserve (DOR) who received intracytoplasmic sperm injection (ICSI) treatment at the Tepecik Training and Research Hospital, Department of Obstetrics and Gynecology, IVF Center, between January 1, 2017, and June 30, 2023, were examined. Within the inclusion and exclusion criteria, 100 cases were identified and divided into three groups based on treatment indications: AZO (n=34), DOR (n=34), and AZO+DOR (n=32). The patients' age, basal hormone levels (FSH, E2, PRG, AMH), treatment indications, embryo transfer days, and clinical pregnancy outcomes were documented.</div></div><div><h3>Results</h3><div>Clinical pregnancy rates were found to be 64.7% in the AZO group, 50% in the DOR group, and 34.4% in the DOR+AZO group. When the groups were compared among themselves, the clinical pregnancy rate in the AZO group was found to be significantly higher than in the DOR+AZO group (p=0.014). When comparing live birth rates among the groups, the live birth rate in the DOR+AZO group was found to be significantly lower than in the AZO group (p=0.022). When the types of pregnancies were examined among the groups, in the DOR group, pregnancies resulted in live births at a rate of 70.6% and in missed abortion at a rate of 29.4%.</div></div><div><h3>Conclusions</h3><div>Clinical pregnancy and live birth rates were found to be significantly higher in the AZO group compared to the DOR+AZO group. We believe that ovarian reserve in women is more determinant of IVF/ICSI success than sperm quality.</div></div>\",\"PeriodicalId\":21134,\"journal\":{\"name\":\"Reproductive biomedicine online\",\"volume\":\"49 \",\"pages\":\"Article 104590\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reproductive biomedicine online\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S147264832400779X\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reproductive biomedicine online","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S147264832400779X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
EFFECT OF OVARIAN RESERVE ON PREGNANCY OUTCOMES IN PATIENTS UNDERGOING IVF TREATMENT DUE TO AZOOSPERMIA
Objective
Infertility is a condition that has been increasingly prevalent in recent years and has demographic, psychological, economic, and medical consequences in society. A review of the literature reveals a large number of studies conducted on azoospermia (AZO) and diminished ovarian reserve (DOR), but there are relatively few studies comparing these two conditions simultaneously. In our study, we aimed to contribute to the literature by comparing these two challenging groups that we treat in our clinic, both from the physician's and the patient's perspective.
Materials and Methods
In our study, patients diagnosed with azoospermia (AZO) and diminished ovarian reserve (DOR) who received intracytoplasmic sperm injection (ICSI) treatment at the Tepecik Training and Research Hospital, Department of Obstetrics and Gynecology, IVF Center, between January 1, 2017, and June 30, 2023, were examined. Within the inclusion and exclusion criteria, 100 cases were identified and divided into three groups based on treatment indications: AZO (n=34), DOR (n=34), and AZO+DOR (n=32). The patients' age, basal hormone levels (FSH, E2, PRG, AMH), treatment indications, embryo transfer days, and clinical pregnancy outcomes were documented.
Results
Clinical pregnancy rates were found to be 64.7% in the AZO group, 50% in the DOR group, and 34.4% in the DOR+AZO group. When the groups were compared among themselves, the clinical pregnancy rate in the AZO group was found to be significantly higher than in the DOR+AZO group (p=0.014). When comparing live birth rates among the groups, the live birth rate in the DOR+AZO group was found to be significantly lower than in the AZO group (p=0.022). When the types of pregnancies were examined among the groups, in the DOR group, pregnancies resulted in live births at a rate of 70.6% and in missed abortion at a rate of 29.4%.
Conclusions
Clinical pregnancy and live birth rates were found to be significantly higher in the AZO group compared to the DOR+AZO group. We believe that ovarian reserve in women is more determinant of IVF/ICSI success than sperm quality.
期刊介绍：
Reproductive BioMedicine Online covers the formation, growth and differentiation of the human embryo. It is intended to bring to public attention new research on biological and clinical research on human reproduction and the human embryo including relevant studies on animals. It is published by a group of scientists and clinicians working in these fields of study. Its audience comprises researchers, clinicians, practitioners, academics and patients.
Context:
The period of human embryonic growth covered is between the formation of the primordial germ cells in the fetus until mid-pregnancy. High quality research on lower animals is included if it helps to clarify the human situation. Studies progressing to birth and later are published if they have a direct bearing on events in the earlier stages of pregnancy.
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