锡(II)-氯化（SnCl2）介导α，β-炔基羰基化合物的还原

IF 1.4 4区化学 Q3 CHEMISTRY, ORGANIC Tetrahedron Letters Pub Date : 2025-02-28 Epub Date: 2025-01-31 DOI:10.1016/j.tetlet.2025.155481

U. Ralepelle , E.N. Agbo , K. Lekgau , H. Chauke , I. Cukrowski , W. Nxumalo

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引用次数: 0

摘要

本文报道了一种由氯化锡（SnCl2）介导的高效还原α，β-炔基羰基化合物为其相应的烷烃的方法。通过对反应时间、温度、SnCl2在不同溶剂中的等效性等参数进行优化。最佳反应条件为2.5等量SnCl2，在25℃条件下，在乙酸乙酯中反应3 h，收率为80%。该方法适用于喹啉、嘧啶、吡嗪和吡啶的α、β-炔基羰基的还原。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tin(II)-chloride (SnCl2) mediated reduction of α,β-alkynyl carbonyl compounds

An efficient Tin(II)-chloride (SnCl₂) mediated reduction of α,β-alkynyl carbonyl compounds to their corresponding alkanes has been developed and reported. The developed method was optimized by varying parameters such as reaction time, temperature, and the equivalence of SnCl₂ using different solvents. The best reaction condition (80 % yield) involved 2.5 eq. of SnCl₂, at 25 °C for 3 h in ethyl acetate. This method is applicable for the reduction of α,β-alkynyl carbonyl of quinoxaline, pyrimidine, pyrazine and pyridine.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.