{"title":"金属有机骨架（MOF）体系中新型肽基四羧酸配体的合成及其应用","authors":"Moustafa Hamaad, Rudolf J. Wehmschulte","doi":"10.1016/j.tet.2024.134387","DOIUrl":null,"url":null,"abstract":"<div><div>Novel peptide-based tetracarboxylate ligands that consist of a pair of isophthalate moieties (ditopic 1,3-benzene dicarboxylate groups) bridged together through their 5-position by a flexible peptide core spacer have been synthesized through solution-phase peptide synthesis based on Boc chemistry (Boc: tert-butyloxycarbonyl). The peptide spacer component of the ligands is based on Glycine-Glycine, Alanine-Glycine, Phenylalanine-Glycine, Tryptophan-Glycine, Serine-Glycine, Aspartic-Glycine dipeptides and the Glycine-Glycine-Glycine tripeptide. These novel linkers are potential candidates as key building blocks for the construction of biomimetic metal-organic frameworks (MOFs).</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"171 ","pages":"Article 134387"},"PeriodicalIF":2.1000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of novel peptide-based tetracarboxylate ligands for metal organic framework (MOF) systems and applications\",\"authors\":\"Moustafa Hamaad, Rudolf J. Wehmschulte\",\"doi\":\"10.1016/j.tet.2024.134387\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Novel peptide-based tetracarboxylate ligands that consist of a pair of isophthalate moieties (ditopic 1,3-benzene dicarboxylate groups) bridged together through their 5-position by a flexible peptide core spacer have been synthesized through solution-phase peptide synthesis based on Boc chemistry (Boc: tert-butyloxycarbonyl). The peptide spacer component of the ligands is based on Glycine-Glycine, Alanine-Glycine, Phenylalanine-Glycine, Tryptophan-Glycine, Serine-Glycine, Aspartic-Glycine dipeptides and the Glycine-Glycine-Glycine tripeptide. These novel linkers are potential candidates as key building blocks for the construction of biomimetic metal-organic frameworks (MOFs).</div></div>\",\"PeriodicalId\":437,\"journal\":{\"name\":\"Tetrahedron\",\"volume\":\"171 \",\"pages\":\"Article 134387\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040402024005684\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040402024005684","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/26 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Synthesis of novel peptide-based tetracarboxylate ligands for metal organic framework (MOF) systems and applications
Novel peptide-based tetracarboxylate ligands that consist of a pair of isophthalate moieties (ditopic 1,3-benzene dicarboxylate groups) bridged together through their 5-position by a flexible peptide core spacer have been synthesized through solution-phase peptide synthesis based on Boc chemistry (Boc: tert-butyloxycarbonyl). The peptide spacer component of the ligands is based on Glycine-Glycine, Alanine-Glycine, Phenylalanine-Glycine, Tryptophan-Glycine, Serine-Glycine, Aspartic-Glycine dipeptides and the Glycine-Glycine-Glycine tripeptide. These novel linkers are potential candidates as key building blocks for the construction of biomimetic metal-organic frameworks (MOFs).
期刊介绍：
Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry.
Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters.
Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.
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