{"title":"羧酸与亚砜酰氯硫代酯化的一种有效方法","authors":"Jiahong Chen, Mengke Wang, Weichun Huang, You Zi","doi":"10.1016/j.tet.2024.134422","DOIUrl":null,"url":null,"abstract":"<div><div>A mild and convenient method for synthesizing thioesters has been developed, from sulfenylchlorides and carboxylic acids via a phosphine mediated umpolung process. This approach efficiently produces a broad spectrum of thioesters from readily available carboxylic acids, including primary, secondary, and tertiary types, as well as bioactive molecules. The successful gram-scale reactions also validate its scalability and practical application.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"171 ","pages":"Article 134422"},"PeriodicalIF":2.2000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An efficient method for thioesterification of carboxylic acid with sulfenylchloride\",\"authors\":\"Jiahong Chen, Mengke Wang, Weichun Huang, You Zi\",\"doi\":\"10.1016/j.tet.2024.134422\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A mild and convenient method for synthesizing thioesters has been developed, from sulfenylchlorides and carboxylic acids via a phosphine mediated umpolung process. This approach efficiently produces a broad spectrum of thioesters from readily available carboxylic acids, including primary, secondary, and tertiary types, as well as bioactive molecules. The successful gram-scale reactions also validate its scalability and practical application.</div></div>\",\"PeriodicalId\":437,\"journal\":{\"name\":\"Tetrahedron\",\"volume\":\"171 \",\"pages\":\"Article 134422\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040402024006033\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040402024006033","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/12 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
An efficient method for thioesterification of carboxylic acid with sulfenylchloride
A mild and convenient method for synthesizing thioesters has been developed, from sulfenylchlorides and carboxylic acids via a phosphine mediated umpolung process. This approach efficiently produces a broad spectrum of thioesters from readily available carboxylic acids, including primary, secondary, and tertiary types, as well as bioactive molecules. The successful gram-scale reactions also validate its scalability and practical application.
期刊介绍：
Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry.
Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters.
Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
