光诱导氢原子转移直接α-碳氢醇烷基化反应。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC Organic & Biomolecular Chemistry Pub Date : 2025-02-05 DOI:10.1039/D4OB01874E

Mingzhong Wu, Yaru Wang, Xin Lv, Zhengxian Ma, Xiaojing Sheng, Mengjie Wang, Yalin Zhang, Zhenyu An and Xuekun Wang

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引用次数: 0

摘要

我们建立了一种α-C-H 醇烷基化的通用方法，以 TBAP 作为助催化剂，通过可见光辐照获得高度官能化的醇。该方法具有出色的官能团耐受性和广泛的底物范围。该方法的实用性通过克级规模的成功合成和阳光驱动的反应演示得到了证明。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Direct α-C–H alkylation of alcohols via photoinduced hydrogen atom transfer†

A general approach for the α-C–H alkylation of alcohols has been established, offering access to highly functionalized alcohols via visible light irradiation with TBAP as a co-catalyst. The methodology exhibits excellent functional group tolerance and a wide substrate scope. Its practicality is underscored by successful gram-scale synthesis and a sunlight-driven reaction demonstration.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.