Non-Surgical Correction of Dermatochalasis Using Microplasma.

Background:  Dermatochalasis is characterized by the presence of redundant and loose upper eyelid skin, which occurs as part of the aging process and is often considered aesthetically undesirable. Currently, the gold standard for treatment is surgical blepharoplasty; however, non-surgical solutions are frequently requested. This study investigates the safety and efficacy of microplasma as a non-surgical method for treating dermatochalasis.

Methods:  Pre-clinic investigations were performed in vivo on porcine skin. Three pigs were treated with an increasing energy exposure of microplasma and biopsy samples were analyzed via histology. Subsequently, in a prospective clinical trial, 13 subjects with dermatochalasis were treated with MicroPlasma applicator. The subjects received 1 to 2 treatments with a treatment interval of 4 to 16 weeks. Results were assessed by blinded evaluation of pre- and post-treatment pictures and a patient questionnaire.

Results:  The in vivo porcine study showed skin ablation and dermal coagulation consistent with increasing plasma energy delivery, and subsequent healing process as expected, with neovascularization and fibroblast proliferation. In the clinical patient trial, blinded evaluations revealed improvement in the Dermatochalasis Scale (P<0.01) and improvement in the Global Aesthetics Improvement Scale. There were no serious adverse events.

Conclusion:  Microplasma is a successful non-surgical treatment option to reduce redundant skin of the upper eyelid with minimal adverse effects. J Drugs Dermatol. 2025;24(2):134-141. doi:10.36849/JDD.8635.