膳食中补充硝酸盐可提高WHO组3肺动脉高压患者的运动能力：一项双盲、安慰剂对照、随机交叉研究（EDEN-OX2）。

IF 9.1 1区医学 Q1 RESPIRATORY SYSTEM Thorax Pub Date : 2025-04-15 DOI:10.1136/thorax-2024-222019

Abdullah S Alsulayyim, Ali M Alasmari, Laura C Price, Colm McCabe, Saeed M Alghamdi, Keir Elmslie James Philip, Sara C Buttery, Matthew J Pavitt, Michael I Polkey, Matthew J Rickman, Blerina Ahmetaj-Shala, Jane A Mitchell, Rami A Alyami, Nicholas S Hopkinson

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引用次数: 0

摘要

膳食中补充硝酸盐可以改善慢性阻塞性肺疾病患者骨骼肌的氧气利用率、血管内皮功能和运动能力，也可能对其他肺部疾病有益。在一项双盲、安慰剂对照、交叉研究中，在19名3组肺动脉高压患者中，与无硝酸盐甜菜根汁安慰剂相比，140毫升富含硝酸盐的甜菜根汁改善了耐力穿梭行走时间（中位数（IQR）） ESWT NR-BRJ 197 (140-273) s vs l - brj 174 (107-229) s；中位差（MD）（95% CI） 30 (6.19 ~ 91.07) s, p=0.0281)，内皮功能，血流介导的扩张(+3.40±5.47% vs -1.33±4.78；MD （95% CI) 4.73 (1.44 ~ 8.02), p=0.007）和平均动脉血压降低（-3.9 (-7.4 ~ -0.4)mmhg, p=0.028）。

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Dietary nitrate supplementation enhances exercise capacity in WHO Group 3 pulmonary hypertension: a double-blind, placebo-controlled, randomised crossover study (EDEN-OX2).

Dietary nitrate supplementation, which improves skeletal muscle oxygen utilisation, vascular endothelial function and exercise capacity in people with chronic obstructive pulmonary disease, may benefit other lung conditions. In a double-blind, placebo-controlled, crossover study, in 19 adults with Group 3 pulmonary hypertension who desaturated during exercise, 140 mL of nitrate-rich beetroot juice improved endurance shuttle walk time compared with nitrate-depleted beetroot juice placebo (median (IQR) ESWT NR-BRJ 197 (140-273) s vs PL-BRJ 174 (107-229) s; median difference (MD) (95% CI) 30 (6.19 to 91.07) s, p=0.0281), endothelial function, flow-mediated dilatation (+3.40±5.47% vs -1.33±4.78; MD (95% CI) 4.73 (1.44 to 8.02), p=0.007) and lowered mean arterial blood pressure (-3.9 (-7.4 to -0.4) mm Hg, p=0.028).

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来源期刊

Thorax 医学-呼吸系统

CiteScore

16.10

自引率

2.00%

发文量

197

审稿时长

1 months

期刊介绍： Thorax stands as one of the premier respiratory medicine journals globally, featuring clinical and experimental research articles spanning respiratory medicine, pediatrics, immunology, pharmacology, pathology, and surgery. The journal's mission is to publish noteworthy advancements in scientific understanding that are poised to influence clinical practice significantly. This encompasses articles delving into basic and translational mechanisms applicable to clinical material, covering areas such as cell and molecular biology, genetics, epidemiology, and immunology.