Yu Liu, Guangxi Piao, Jie Chen, Guangyou Duan, Ling Dan, Guizhen Chen, Yamei Zhang
{"title":"右星状神经节阻滞对预防妇科腹腔镜术后恶心呕吐的影响：一项随机对照试验。","authors":"Yu Liu, Guangxi Piao, Jie Chen, Guangyou Duan, Ling Dan, Guizhen Chen, Yamei Zhang","doi":"10.1007/s12325-025-03109-7","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Postoperative nausea and vomiting (PONV) is one of the most common postoperative complications, with particularly high rates in patients undergoing high-risk surgeries such as gynecologic laparoscopy. Although there are many pharmacological and non-pharmacological methods that can prevent PONV, the incidence remains high. This study assessed the effectiveness of a right stellate ganglion block (SGB) in preventing PONV in gynecological laparoscopy patients, while also exploring the potential mechanisms involved.</p><h3>Methods</h3><p>Two hundred patients were randomly assigned to either a right SGB under ultrasound guidance 30 min before anesthesia (SGB group) or no treatment (control group). The primary outcome was PONV incidence within 24 h post surgery. Secondary outcomes included nausea and vomiting severity, pain scores, postoperative flatus time, sleep quality, and satisfaction scores.</p><h3>Results</h3><p>The incidence of PONV in the SGB group was 38%, significantly lower than the 60% in the control group (<i>P</i> = 0.002). Severity of PONV was also notably reduced in the SGB group (<i>P</i> = 0.004). Resting pain scores in the SGB group at 6 h (0.0 [0.0, 1.0] vs. 0.0 [0.0, 2.0], <i>P</i> = 0.013), 12 h (0.0 [0.0, 1.0] vs. 0.0 [0.0, 2.0], <i>P</i> = 0.027), and 24 h (0.0 [0.0, 1.0] vs. 0.0 [0.0, 2.0], <i>P</i> = 0.011) were lower than in the control group. Post-activity pain scores at 6 h (2.0 [1.0, 3.0] vs. 3.0 [1.25, 4.0], <i>P</i> = 0.000), 12 h (2.0 [1.0, 3.0] vs. 3.0 [1.25, 4.0], <i>P</i> = 0.002), and 24 h (2.0 [1.0, 3.0] vs. 3.0 [2.0, 4.0], <i>P</i> = 0.001) were also lower. The time to first postoperative flatus was shorter in the SGB group (<i>P</i> = 0.033). Overall postoperative satisfaction (<i>P</i> = 0.002) and analgesia satisfaction (<i>P</i> = 0.002) were higher, and sleep quality was improved (<i>P</i> = 0.046).</p><h3>Conclusion</h3><p>A right stellate ganglion block reduces PONV, pain, and postoperative flatus time, and improves sleep quality and satisfaction in gynecological laparoscopy patients, proving it to be a safe and effective method.</p><p><b>Trial Registration</b>: NCT06426186.</p></div>","PeriodicalId":7482,"journal":{"name":"Advances in Therapy","volume":"42 3","pages":"1537 - 1549"},"PeriodicalIF":4.0000,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Right Stellate Ganglion Block on Preventing Postoperative Nausea and Vomiting in Gynecological Laparoscopic Patients: A Randomized Controlled Trial\",\"authors\":\"Yu Liu, Guangxi Piao, Jie Chen, Guangyou Duan, Ling Dan, Guizhen Chen, Yamei Zhang\",\"doi\":\"10.1007/s12325-025-03109-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Postoperative nausea and vomiting (PONV) is one of the most common postoperative complications, with particularly high rates in patients undergoing high-risk surgeries such as gynecologic laparoscopy. Although there are many pharmacological and non-pharmacological methods that can prevent PONV, the incidence remains high. This study assessed the effectiveness of a right stellate ganglion block (SGB) in preventing PONV in gynecological laparoscopy patients, while also exploring the potential mechanisms involved.</p><h3>Methods</h3><p>Two hundred patients were randomly assigned to either a right SGB under ultrasound guidance 30 min before anesthesia (SGB group) or no treatment (control group). The primary outcome was PONV incidence within 24 h post surgery. Secondary outcomes included nausea and vomiting severity, pain scores, postoperative flatus time, sleep quality, and satisfaction scores.</p><h3>Results</h3><p>The incidence of PONV in the SGB group was 38%, significantly lower than the 60% in the control group (<i>P</i> = 0.002). Severity of PONV was also notably reduced in the SGB group (<i>P</i> = 0.004). Resting pain scores in the SGB group at 6 h (0.0 [0.0, 1.0] vs. 0.0 [0.0, 2.0], <i>P</i> = 0.013), 12 h (0.0 [0.0, 1.0] vs. 0.0 [0.0, 2.0], <i>P</i> = 0.027), and 24 h (0.0 [0.0, 1.0] vs. 0.0 [0.0, 2.0], <i>P</i> = 0.011) were lower than in the control group. Post-activity pain scores at 6 h (2.0 [1.0, 3.0] vs. 3.0 [1.25, 4.0], <i>P</i> = 0.000), 12 h (2.0 [1.0, 3.0] vs. 3.0 [1.25, 4.0], <i>P</i> = 0.002), and 24 h (2.0 [1.0, 3.0] vs. 3.0 [2.0, 4.0], <i>P</i> = 0.001) were also lower. The time to first postoperative flatus was shorter in the SGB group (<i>P</i> = 0.033). Overall postoperative satisfaction (<i>P</i> = 0.002) and analgesia satisfaction (<i>P</i> = 0.002) were higher, and sleep quality was improved (<i>P</i> = 0.046).</p><h3>Conclusion</h3><p>A right stellate ganglion block reduces PONV, pain, and postoperative flatus time, and improves sleep quality and satisfaction in gynecological laparoscopy patients, proving it to be a safe and effective method.</p><p><b>Trial Registration</b>: NCT06426186.</p></div>\",\"PeriodicalId\":7482,\"journal\":{\"name\":\"Advances in Therapy\",\"volume\":\"42 3\",\"pages\":\"1537 - 1549\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-02-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12325-025-03109-7\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Therapy","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12325-025-03109-7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Effect of Right Stellate Ganglion Block on Preventing Postoperative Nausea and Vomiting in Gynecological Laparoscopic Patients: A Randomized Controlled Trial
Introduction
Postoperative nausea and vomiting (PONV) is one of the most common postoperative complications, with particularly high rates in patients undergoing high-risk surgeries such as gynecologic laparoscopy. Although there are many pharmacological and non-pharmacological methods that can prevent PONV, the incidence remains high. This study assessed the effectiveness of a right stellate ganglion block (SGB) in preventing PONV in gynecological laparoscopy patients, while also exploring the potential mechanisms involved.
Methods
Two hundred patients were randomly assigned to either a right SGB under ultrasound guidance 30 min before anesthesia (SGB group) or no treatment (control group). The primary outcome was PONV incidence within 24 h post surgery. Secondary outcomes included nausea and vomiting severity, pain scores, postoperative flatus time, sleep quality, and satisfaction scores.
Results
The incidence of PONV in the SGB group was 38%, significantly lower than the 60% in the control group (P = 0.002). Severity of PONV was also notably reduced in the SGB group (P = 0.004). Resting pain scores in the SGB group at 6 h (0.0 [0.0, 1.0] vs. 0.0 [0.0, 2.0], P = 0.013), 12 h (0.0 [0.0, 1.0] vs. 0.0 [0.0, 2.0], P = 0.027), and 24 h (0.0 [0.0, 1.0] vs. 0.0 [0.0, 2.0], P = 0.011) were lower than in the control group. Post-activity pain scores at 6 h (2.0 [1.0, 3.0] vs. 3.0 [1.25, 4.0], P = 0.000), 12 h (2.0 [1.0, 3.0] vs. 3.0 [1.25, 4.0], P = 0.002), and 24 h (2.0 [1.0, 3.0] vs. 3.0 [2.0, 4.0], P = 0.001) were also lower. The time to first postoperative flatus was shorter in the SGB group (P = 0.033). Overall postoperative satisfaction (P = 0.002) and analgesia satisfaction (P = 0.002) were higher, and sleep quality was improved (P = 0.046).
Conclusion
A right stellate ganglion block reduces PONV, pain, and postoperative flatus time, and improves sleep quality and satisfaction in gynecological laparoscopy patients, proving it to be a safe and effective method.
期刊介绍：
Advances in Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged.
The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Advances in Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
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