固体铅微电极吸附溶出伏安法快速灵敏测定枸橼酸西地那非

IF 4.1 3区化学 Q1 CHEMISTRY, ANALYTICAL Journal of Electroanalytical Chemistry Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI:10.1016/j.jelechem.2025.119000

Mateusz Ochab

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引用次数: 0

摘要

采用固态铅微电极（PbµE），采用溶出法快速、灵敏地测定制剂中枸橼酸西地那非的含量。该方法通过吸附过程将SC积累在直径为25µm的固体铅微电极上。在剥离步骤中，SC还原得到了−1.22 （P1）和−1.31 V （P2）两个形状良好的还原峰。P1和P2在5 × 10−10 ~ 2 × 10−8 mol/L范围内与SC在180 s积累时间内的校准曲线呈线性关系，检出限分别为1.8 × 10−10和2.4 × 10−10 mol/L。与铅膜电极相比，固体铅微电极具有良好的重复性（n = 10时RSD为4,2%），长时间耐用性和更环保的特点。该方法成功地应用于某制剂中SC的测定。

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Rapid and sensitive determination of sildenafil citrate by adsorption stripping voltammetry using a solid lead microelectrode

A solid state lead microelectrode (PbµE), was used for the rapid and sensitive determination of sildenafil citrate (SC) in pharmaceutical formulations by the stripping method. The method involves the accumulation of SC on a solid lead microelectrode with diameter of 25 µm, by an adsorption process. In the stripping step, two well-formed reduction peaks at −1.22 (P₁) and −1.31 V (P₂) were obtained during SC reduction. The calibration curve of SC for 180 s accumulation time was linear in the range from 5 × 10⁻¹⁰ to 2 × 10⁻⁸ mol/L for P₁ and P₂, while the detection limit was 1.8 × 10⁻¹⁰ and 2.4 × 10⁻¹⁰ mol/L, respectively. The solid lead microelectrode demonstrated good repeatability (RSD 4,2% for n = 10), durability for a long period of time and its more eco-friendly as compared to lead film electrodes. The procedure was successfully applied to the determination of SC in a pharmaceutical formulations.

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来源期刊

Journal of Electroanalytical Chemistry 化学-电化学

CiteScore

7.80

自引率

6.70%

发文量

912

审稿时长

2.4 months

期刊介绍： The Journal of Electroanalytical Chemistry is the foremost international journal devoted to the interdisciplinary subject of electrochemistry in all its aspects, theoretical as well as applied. Electrochemistry is a wide ranging area that is in a state of continuous evolution. Rather than compiling a long list of topics covered by the Journal, the editors would like to draw particular attention to the key issues of novelty, topicality and quality. Papers should present new and interesting electrochemical science in a way that is accessible to the reader. The presentation and discussion should be at a level that is consistent with the international status of the Journal. Reports describing the application of well-established techniques to problems that are essentially technical will not be accepted. Similarly, papers that report observations but fail to provide adequate interpretation will be rejected by the Editors. Papers dealing with technical electrochemistry should be submitted to other specialist journals unless the authors can show that their work provides substantially new insights into electrochemical processes.