Huazheng Wang, Yixin Chen, Shiqi Liu, Jiaxi Xu, Ning Chen
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Multicomponent Tf2O-Triggered Dearomative Triazinylmethylation of Isoquinolines Using Acetonitrile
A Tf2O-triggered dearomative triazinylmethylation of isoquinolines and other azaarenes utilizing acetonitrile as the nucleophile has been developed through a formal five-component reaction. This method showcases a broad substrate scope and exceptional functional group compatibility, presenting a mild and expedient synthetic approach. Kinetic studies, including kinetic isotope effect (KIE) and Hammett analysis, indicate that the activation of isoquinolines by Tf2O constitutes the rate-limiting step.
期刊介绍：
Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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