A A Boshchenko, B K Kurbatov, M Kilin, L N Maslov, N V Naryzhnaya, V V Saushkin, K V Zavadovsky, I V Stepanov, S V Gusakova, Yu G Birulina, T N Zaitseva, L V Smagliy
{"title":"Role of β-Adrenergic Receptors in Stress-Induced Cardiac Injury.","authors":"A A Boshchenko, B K Kurbatov, M Kilin, L N Maslov, N V Naryzhnaya, V V Saushkin, K V Zavadovsky, I V Stepanov, S V Gusakova, Yu G Birulina, T N Zaitseva, L V Smagliy","doi":"10.1007/s10517-025-06327-9","DOIUrl":null,"url":null,"abstract":"<p><p>Stress-induced cardiac injury (SICI) was modeled on female Wistar rats using a 24-h immobilization. SICI was quantified by <sup>99m</sup>Tc-pyrophosphate accumulation in the myocardium. Blockade of β<sub>1</sub>- and β<sub>2</sub>-adrenergic receptors (AR) led to a decrease in SICI. β<sub>1</sub>-AR antagonists nebivolol and atenolol almost completely prevented SICI. The selective β<sub>2</sub>-AR antagonist ICI 118,551 increased SICI, while the selective β<sub>3</sub>-AR antagonist L-748337 did not affect heart damage. The selective β<sub>2</sub>-AR agonist formoterol increased cardiac tolerance to stress. These findings suggest that β<sub>1</sub>-AR play a key role in the pathogenesis of SICI. Stimulation of β<sub>2</sub>-AR enhances cardiac tolerance to stress. β<sub>3</sub>-AR are not involved in the pathogenesis of SICI.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"311-314"},"PeriodicalIF":0.9000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06327-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/13 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Role of β-Adrenergic Receptors in Stress-Induced Cardiac Injury.
Stress-induced cardiac injury (SICI) was modeled on female Wistar rats using a 24-h immobilization. SICI was quantified by 99mTc-pyrophosphate accumulation in the myocardium. Blockade of β1- and β2-adrenergic receptors (AR) led to a decrease in SICI. β1-AR antagonists nebivolol and atenolol almost completely prevented SICI. The selective β2-AR antagonist ICI 118,551 increased SICI, while the selective β3-AR antagonist L-748337 did not affect heart damage. The selective β2-AR agonist formoterol increased cardiac tolerance to stress. These findings suggest that β1-AR play a key role in the pathogenesis of SICI. Stimulation of β2-AR enhances cardiac tolerance to stress. β3-AR are not involved in the pathogenesis of SICI.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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