IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Nature biotechnology Pub Date : 2025-02-14 DOI:10.1038/s41587-025-02578-z
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摘要

现实版《侏罗纪公园》中的初创公司Colossal BioSciences于1月15日宣布,它已筹集到2亿美元,用于复活三种已灭绝的动物:长毛猛犸象、塔斯马尼亚虎和渡渡鸟。复活已灭绝的古老物种将是一项创举,需要Colossal公司的研究人员克服一些巨大的挑战。该公司表示,它已经积累了长毛猛犸象(Mammuthus primigenius)、塔斯马尼亚虎(Thylacinus cynocephalus)和渡渡鸟(Raphus cucullatus)最连续、最完整的基因组。但是,要实现从远古基因组到活体物种的转变,需要在计算生物学、细胞工程、基因工程、胚胎学和动物饲养等多个领域取得重大进展。如果该公司取得成功,复活的动物将不会与其远古前辈完全相同;相反,它们将是相关活体物种遗传和环境特征的产物。为了制造长毛猛犸象,Colossal 公司的研究人员计划编辑 85 个大象基因,开发细胞系,将细胞核与亚洲象卵融合,然后将编辑好的胚胎植入亚洲象或非洲象代孕体内。为了让渡渡鸟复活,Colossal 公司将求助于渡渡鸟的近亲--尼科巴鸽(Caloenas nicobarica)。至于塔斯马尼亚虎,该公司则依赖于肥尾杜父鱼(Sminthopsis crassicaudata)。这项工作将结合多重基因组编辑、人造子宫和野生鸟类原始生殖细胞的生长。
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来源期刊
Nature biotechnology
Nature biotechnology 工程技术-生物工程与应用微生物
CiteScore
63.00
自引率
1.70%
发文量
382
审稿时长
3 months
期刊介绍: Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research. The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field. Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology. In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.
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