Guang-Chuan Xu , Liang Zeng , Ming Hu , Fu-Jin Sun , Jin-Heng Li
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Photoredox β-C(sp3)–H heteroarylation of o-iodoaryl-alkan-1-ones with heteroarenes via HAT and dual C–H functionalizations†
A synthetically useful method for the formal β-heteroarylation of ketones via an iodoarene-directed photoredox remote C(sp3)–H heteroarylation of o-iodoarylalkan-1-ones with heteroarenes is reported. This protocol relies on single electron transfer (SET), hydrogen atom transfer (HAT) and dual C–H functionalizations leading to β-heteroaryl ketones. This mild method displays broad scope, good functional group compatibility, high atom economy and excellent selectivity control.
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