Guang-Chuan Xu, Liang Zeng, Ming Hu, Fujin Sun, Jin-Heng Li
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Photoredox β-C(sp3)-H Heteroarylation of o-Iodoaryl-alkan-1-ones with Heteroarenes via HAT and Dual C-H Functionalizations
A synthetically useful method for the formal β-heteroarylation of ketones via an iodoarene-directed photoredox remote C(sp3)−H heteroarylation of o-iodoarylalkan-1-ones with heteroarenes is reported. This protocol relies on single electron transfer (SET), hydrogen atom transfer (HAT) and dual C-H functionalizations leading to β-heteroaryl ketones. This mild method displays a broad scope, a good functional group compatibility, a high atom economy and an excellent selectivity control.
期刊介绍：
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.
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