{"title":"c3和c4补体单克隆抗体的血清学鉴定","authors":"D. Voak, D.N. Downie","doi":"10.1016/S0338-4535(88)80125-9","DOIUrl":null,"url":null,"abstract":"<div><p>Six monoclonal antibodies to complement components were evaluated, five detected components of C 3 and the other reacted with C 4.</p><p>The specificity and titre of antibodies to the various complement components is easily determined by the use of C 3 and C 4 coated red cells prepared by low ionic methods. These procedures have been reviewed by <span>Voak</span> <em>and al.</em> [5] and <span>Engelfriet</span> <em>and al.</em> [1] as a result of studies by a joint working party of the ISBT/ICSH on the standardization of anti-human globulin reagents.</p><p>The aim of this paper is to establish a simple procedure for the characterization of antibodies to C 3/C 4 complement components, as shown in <em>Table I</em>.</p></div>","PeriodicalId":101128,"journal":{"name":"Revue Fran?aise de Transfusion et Immuno-hématologie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0338-4535(88)80125-9","citationCount":"2","resultStr":"{\"title\":\"Serological characterization of monoclonal antibodies to complement components of C 3 and C 4\",\"authors\":\"D. Voak, D.N. Downie\",\"doi\":\"10.1016/S0338-4535(88)80125-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Six monoclonal antibodies to complement components were evaluated, five detected components of C 3 and the other reacted with C 4.</p><p>The specificity and titre of antibodies to the various complement components is easily determined by the use of C 3 and C 4 coated red cells prepared by low ionic methods. These procedures have been reviewed by <span>Voak</span> <em>and al.</em> [5] and <span>Engelfriet</span> <em>and al.</em> [1] as a result of studies by a joint working party of the ISBT/ICSH on the standardization of anti-human globulin reagents.</p><p>The aim of this paper is to establish a simple procedure for the characterization of antibodies to C 3/C 4 complement components, as shown in <em>Table I</em>.</p></div>\",\"PeriodicalId\":101128,\"journal\":{\"name\":\"Revue Fran?aise de Transfusion et Immuno-hématologie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0338-4535(88)80125-9\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revue Fran?aise de Transfusion et Immuno-hématologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0338453588801259\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revue Fran?aise de Transfusion et Immuno-hématologie","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0338453588801259","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Serological characterization of monoclonal antibodies to complement components of C 3 and C 4
Six monoclonal antibodies to complement components were evaluated, five detected components of C 3 and the other reacted with C 4.
The specificity and titre of antibodies to the various complement components is easily determined by the use of C 3 and C 4 coated red cells prepared by low ionic methods. These procedures have been reviewed by Voakand al. [5] and Engelfrietand al. [1] as a result of studies by a joint working party of the ISBT/ICSH on the standardization of anti-human globulin reagents.
The aim of this paper is to establish a simple procedure for the characterization of antibodies to C 3/C 4 complement components, as shown in Table I.
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