Juan-Francisco Calvo-Ortega, Coral Laosa-Bello, Sandra Moragues-Femenía, José Torices-Caballero, Miguel Pozo-Massó, Adam Jones, Marcelino Hermida-López
{"title":"ONLINE ADAPTIVE FIVE-FRACTION ABLATIVE RADIOTHERAPY FOR PROSTATE CANCER USING A CONVENTIONAL LINEAR ACCELERATOR.","authors":"Juan-Francisco Calvo-Ortega, Coral Laosa-Bello, Sandra Moragues-Femenía, José Torices-Caballero, Miguel Pozo-Massó, Adam Jones, Marcelino Hermida-López","doi":"10.1016/j.prro.2025.01.013","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To assess the dosimetric results of an online adaptive stereotactic body radiotherapy (SBRT) program to treat patients with prostate cancer using a conventional linear accelerator.</p><p><strong>Methods and materials: </strong>Prostate SBRT with five fractions is performed at the XXXX using an online adaptive method previously described (XXXX). A CBCT based adaptive \"plan-of-the-day\" (POD) is generated for each treatment fraction, which consists of a single volumetric modulated arc therapy. A dosimetric evaluation of the PODs was performed for the first twenty patients and included analysis of the target (prostate), organs-at-risks (OARs), and patient-specific quality assurance (PSQA). Each of the PODs was also compared with the corresponding conventional image-guided radiotherapy (IGRT) method. Finally, the adaptive treatment timing is analyzed for the one hundred PODs in this study RESULTS: The online adaptive treatment method ensured optimal target coverage in all treatment fractions for all patients. However, the simulated IGRT plans did not result in adequate prostate coverage (V40 Gy ≥ 95%) in 70% of fractions. Small average differences between PODs and IGRT plans were found in the OARs. The dose sparing in the rectum and bladder provided by some simulated IGRT plans, was associated with a compromised prostate coverage. The PSQA resulted in an excellent agreement between the online-calculated plans and the independent dose checks performed for all one hundred PODs. The average duration of the plan adaptation was 20.1 ± 6.1 minutes and the average overall session time including adaptation and treatment delivery was 26.4 ± 33.2 minutes.</p><p><strong>Conclusions: </strong>This study demonstrates The online adaptive program using a conventional linac to treat prostate cancer described in this study is clinically feasible and in adherence with the acceptance criteria set by the PACE B.</p><p><strong>Trial: </strong></p>","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Practical Radiation Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.prro.2025.01.013","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
ONLINE ADAPTIVE FIVE-FRACTION ABLATIVE RADIOTHERAPY FOR PROSTATE CANCER USING A CONVENTIONAL LINEAR ACCELERATOR.
Aim: To assess the dosimetric results of an online adaptive stereotactic body radiotherapy (SBRT) program to treat patients with prostate cancer using a conventional linear accelerator.
Methods and materials: Prostate SBRT with five fractions is performed at the XXXX using an online adaptive method previously described (XXXX). A CBCT based adaptive "plan-of-the-day" (POD) is generated for each treatment fraction, which consists of a single volumetric modulated arc therapy. A dosimetric evaluation of the PODs was performed for the first twenty patients and included analysis of the target (prostate), organs-at-risks (OARs), and patient-specific quality assurance (PSQA). Each of the PODs was also compared with the corresponding conventional image-guided radiotherapy (IGRT) method. Finally, the adaptive treatment timing is analyzed for the one hundred PODs in this study RESULTS: The online adaptive treatment method ensured optimal target coverage in all treatment fractions for all patients. However, the simulated IGRT plans did not result in adequate prostate coverage (V40 Gy ≥ 95%) in 70% of fractions. Small average differences between PODs and IGRT plans were found in the OARs. The dose sparing in the rectum and bladder provided by some simulated IGRT plans, was associated with a compromised prostate coverage. The PSQA resulted in an excellent agreement between the online-calculated plans and the independent dose checks performed for all one hundred PODs. The average duration of the plan adaptation was 20.1 ± 6.1 minutes and the average overall session time including adaptation and treatment delivery was 26.4 ± 33.2 minutes.
Conclusions: This study demonstrates The online adaptive program using a conventional linac to treat prostate cancer described in this study is clinically feasible and in adherence with the acceptance criteria set by the PACE B.
期刊介绍：
The overarching mission of Practical Radiation Oncology is to improve the quality of radiation oncology practice. PRO''s purpose is to document the state of current practice, providing background for those in training and continuing education for practitioners, through discussion and illustration of new techniques, evaluation of current practices, and publication of case reports. PRO strives to provide its readers content that emphasizes knowledge "with a purpose." The content of PRO includes:
Original articles focusing on patient safety, quality measurement, or quality improvement initiatives
Original articles focusing on imaging, contouring, target delineation, simulation, treatment planning, immobilization, organ motion, and other practical issues
ASTRO guidelines, position papers, and consensus statements
Essays that highlight enriching personal experiences in caring for cancer patients and their families.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
