{"title":"一种用于炭疽生物标志物视觉检测的镧系金属有机骨架比例荧光传感器","authors":"Hao Zhang , Jvxin Hao , Runnan Wang , Fanxu Meng","doi":"10.1016/j.talanta.2025.127753","DOIUrl":null,"url":null,"abstract":"<div><div>A novel dual-emission fluorescence probe, Eu-TDA-DHTP, was developed based on a ratiometric fluorescence-organic frameworks utilizing Eu<sup>3+</sup>, 2,5-Thiophenedicarboxylic acid, and 2,5-dihydroxyterephthalic acid for the ratiometric and fluorescent visual sensing of the anthrax biomarker 2,6-pyridine dicarboxylic acid (DPA). The experiments demonstrated that this material can effectively enhance dual emission for DPA detection, enabling clear visualization. The limit of detection for DPA detection using Eu-TDA-DHTP is 1.9 μmol/L in fluorometric mode and 5 μmol/L in colorimetric mode. Additionally, the preparation of the Eu-TDA-DHTP@PVP composite matrix membrane and the development of a smartphone-assisted visual assay have enhanced the convenience of DPA detection in serum and urine samples. This study presents a sensitive, efficient, and user-friendly platform for the visual monitoring of DPA, an anthrax biomarker, in real samples.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"288 ","pages":"Article 127753"},"PeriodicalIF":6.1000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A lanthanide metal organic frameworks ratiometric fluorescence sensor for visual detection of anthrax biomarker\",\"authors\":\"Hao Zhang , Jvxin Hao , Runnan Wang , Fanxu Meng\",\"doi\":\"10.1016/j.talanta.2025.127753\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A novel dual-emission fluorescence probe, Eu-TDA-DHTP, was developed based on a ratiometric fluorescence-organic frameworks utilizing Eu<sup>3+</sup>, 2,5-Thiophenedicarboxylic acid, and 2,5-dihydroxyterephthalic acid for the ratiometric and fluorescent visual sensing of the anthrax biomarker 2,6-pyridine dicarboxylic acid (DPA). The experiments demonstrated that this material can effectively enhance dual emission for DPA detection, enabling clear visualization. The limit of detection for DPA detection using Eu-TDA-DHTP is 1.9 μmol/L in fluorometric mode and 5 μmol/L in colorimetric mode. Additionally, the preparation of the Eu-TDA-DHTP@PVP composite matrix membrane and the development of a smartphone-assisted visual assay have enhanced the convenience of DPA detection in serum and urine samples. This study presents a sensitive, efficient, and user-friendly platform for the visual monitoring of DPA, an anthrax biomarker, in real samples.</div></div>\",\"PeriodicalId\":435,\"journal\":{\"name\":\"Talanta\",\"volume\":\"288 \",\"pages\":\"Article 127753\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Talanta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0039914025002437\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/15 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Talanta","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0039914025002437","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/15 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
A lanthanide metal organic frameworks ratiometric fluorescence sensor for visual detection of anthrax biomarker
A novel dual-emission fluorescence probe, Eu-TDA-DHTP, was developed based on a ratiometric fluorescence-organic frameworks utilizing Eu3+, 2,5-Thiophenedicarboxylic acid, and 2,5-dihydroxyterephthalic acid for the ratiometric and fluorescent visual sensing of the anthrax biomarker 2,6-pyridine dicarboxylic acid (DPA). The experiments demonstrated that this material can effectively enhance dual emission for DPA detection, enabling clear visualization. The limit of detection for DPA detection using Eu-TDA-DHTP is 1.9 μmol/L in fluorometric mode and 5 μmol/L in colorimetric mode. Additionally, the preparation of the Eu-TDA-DHTP@PVP composite matrix membrane and the development of a smartphone-assisted visual assay have enhanced the convenience of DPA detection in serum and urine samples. This study presents a sensitive, efficient, and user-friendly platform for the visual monitoring of DPA, an anthrax biomarker, in real samples.
期刊介绍：
Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome.
Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.
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