血管参与骨愈合：与年龄增长和发病率相关的含义

IF 5.1 3区医学 Q2 CELL BIOLOGY Mechanisms of Ageing and Development Pub Date : 2025-04-01 Epub Date: 2025-02-14 DOI:10.1016/j.mad.2025.112041

Rhonda D. Prisby

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引用次数: 0

摘要

骨折不愈合及其相关的发病率是一个全球性的健康问题。虽然骨折后的骨愈合需要许多因素，但血管系统是必不可少的。重要的考虑因素包括骨和骨髓中的血管形态和组织血流的调节。这篇综述讨论了骨折治疗的类型和相关的骨修复（即膜内和软骨内），骨愈合的阶段，以及骨血管网络的作用。最后，骨折愈合是在高龄和发病率的背景下考虑的。

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Vascular participation in bone healing: Implications related to advancing age and morbidity

Fracture non-union and the related morbidities represent a global health concern. While many factors are necessary for proper bone healing following fracture, the vascular system is requisite. Important considerations include vascular morphology in bone and marrow and the regulation of tissue blood flow. This review discusses the types of fracture management and associated bone repair (i.e., intramembranous vs. endochondral), the phases of bone healing, and the role of the bone vascular network. Finally, fracture healing is considered in the context of advanced age and morbidity.

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.